A blood-based diagnostic test incorporating plasma Aβ42/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: findings from a multi cohort validity analysis

BACKGROUND: The development of blood-based biomarker tests that are accurate and robust for Alzheimer’s disease (AD) pathology have the potential to aid clinical diagnosis and facilitate enrollment in AD drug trials. We developed a high-resolution mass spectrometry (MS)-based test that quantifies pl...

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Detalles Bibliográficos
Autores principales: West, Tim, Kirmess, Kristopher M., Meyer, Matthew R., Holubasch, Mary S., Knapik, Stephanie S., Hu, Yan, Contois, John H., Jackson, Erin N., Harpstrite, Scott E., Bateman, Randall J., Holtzman, David M., Verghese, Philip B., Fogelman, Ilana, Braunstein, Joel B., Yarasheski, Kevin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088704/
https://www.ncbi.nlm.nih.gov/pubmed/33933117
http://dx.doi.org/10.1186/s13024-021-00451-6

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