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Rare case of immunoglobulin G4‐related disease arising in gonadal glands with long‐term remission without steroid treatment: Discussion and literature review

INTRODUCTION: Immunoglobulin G4‐related disease embraces a wide range of extra‐pancreatic manifestations. However, localized pathogenesis in gonadal glands, including testes or seminal vesicles, is rare. The clinical course and therapeutic strategy for this disease have not been clearly characterize...

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Autores principales: Isobe, Teruki, Naiki, Taku, Naiki‐Ito, Aya, Kawai, Tatsuya, Etani, Toshiki, Nagai, Takashi, Nozaki, Satoshi, Kobayakawa, Yuki, Iwatsuki, Shoichiro, Matsuyama, Nayuka, Kato, Hiroyuki, Kawai, Noriyasu, Yasui, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088880/
https://www.ncbi.nlm.nih.gov/pubmed/33977256
http://dx.doi.org/10.1002/iju5.12279
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author Isobe, Teruki
Naiki, Taku
Naiki‐Ito, Aya
Kawai, Tatsuya
Etani, Toshiki
Nagai, Takashi
Nozaki, Satoshi
Kobayakawa, Yuki
Iwatsuki, Shoichiro
Matsuyama, Nayuka
Kato, Hiroyuki
Kawai, Noriyasu
Yasui, Takahiro
author_facet Isobe, Teruki
Naiki, Taku
Naiki‐Ito, Aya
Kawai, Tatsuya
Etani, Toshiki
Nagai, Takashi
Nozaki, Satoshi
Kobayakawa, Yuki
Iwatsuki, Shoichiro
Matsuyama, Nayuka
Kato, Hiroyuki
Kawai, Noriyasu
Yasui, Takahiro
author_sort Isobe, Teruki
collection PubMed
description INTRODUCTION: Immunoglobulin G4‐related disease embraces a wide range of extra‐pancreatic manifestations. However, localized pathogenesis in gonadal glands, including testes or seminal vesicles, is rare. The clinical course and therapeutic strategy for this disease have not been clearly characterized. CASE PRESENTATION: A 61‐year‐old Asian male had a left orchiectomy and right seminal vesicle biopsy because of a mass in the left testis and right seminal vesicle. Histological findings showed an infiltration of immunoglobulin G4‐positive plasma cells in the respective tissues and met immunoglobulin G4‐related disease diagnostic criteria. No recurrence and exacerbation have been observed after 12 years’ follow‐up without any clinical intervention. To date, immunoglobulin G4‐related disease in gonadal tissue is rare. This is the first case with mass‐forming lesions in both the testis and seminal vesicle. CONCLUSION: Based on the clinical course of our case and the literature, for patients with accurately diagnosed inactive gonadal immunoglobulin G4‐related disease, watchful waiting is a feasible clinical treatment option.
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spelling pubmed-80888802021-05-10 Rare case of immunoglobulin G4‐related disease arising in gonadal glands with long‐term remission without steroid treatment: Discussion and literature review Isobe, Teruki Naiki, Taku Naiki‐Ito, Aya Kawai, Tatsuya Etani, Toshiki Nagai, Takashi Nozaki, Satoshi Kobayakawa, Yuki Iwatsuki, Shoichiro Matsuyama, Nayuka Kato, Hiroyuki Kawai, Noriyasu Yasui, Takahiro IJU Case Rep Case Reports INTRODUCTION: Immunoglobulin G4‐related disease embraces a wide range of extra‐pancreatic manifestations. However, localized pathogenesis in gonadal glands, including testes or seminal vesicles, is rare. The clinical course and therapeutic strategy for this disease have not been clearly characterized. CASE PRESENTATION: A 61‐year‐old Asian male had a left orchiectomy and right seminal vesicle biopsy because of a mass in the left testis and right seminal vesicle. Histological findings showed an infiltration of immunoglobulin G4‐positive plasma cells in the respective tissues and met immunoglobulin G4‐related disease diagnostic criteria. No recurrence and exacerbation have been observed after 12 years’ follow‐up without any clinical intervention. To date, immunoglobulin G4‐related disease in gonadal tissue is rare. This is the first case with mass‐forming lesions in both the testis and seminal vesicle. CONCLUSION: Based on the clinical course of our case and the literature, for patients with accurately diagnosed inactive gonadal immunoglobulin G4‐related disease, watchful waiting is a feasible clinical treatment option. John Wiley and Sons Inc. 2021-03-15 /pmc/articles/PMC8088880/ /pubmed/33977256 http://dx.doi.org/10.1002/iju5.12279 Text en © 2021 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Isobe, Teruki
Naiki, Taku
Naiki‐Ito, Aya
Kawai, Tatsuya
Etani, Toshiki
Nagai, Takashi
Nozaki, Satoshi
Kobayakawa, Yuki
Iwatsuki, Shoichiro
Matsuyama, Nayuka
Kato, Hiroyuki
Kawai, Noriyasu
Yasui, Takahiro
Rare case of immunoglobulin G4‐related disease arising in gonadal glands with long‐term remission without steroid treatment: Discussion and literature review
title Rare case of immunoglobulin G4‐related disease arising in gonadal glands with long‐term remission without steroid treatment: Discussion and literature review
title_full Rare case of immunoglobulin G4‐related disease arising in gonadal glands with long‐term remission without steroid treatment: Discussion and literature review
title_fullStr Rare case of immunoglobulin G4‐related disease arising in gonadal glands with long‐term remission without steroid treatment: Discussion and literature review
title_full_unstemmed Rare case of immunoglobulin G4‐related disease arising in gonadal glands with long‐term remission without steroid treatment: Discussion and literature review
title_short Rare case of immunoglobulin G4‐related disease arising in gonadal glands with long‐term remission without steroid treatment: Discussion and literature review
title_sort rare case of immunoglobulin g4‐related disease arising in gonadal glands with long‐term remission without steroid treatment: discussion and literature review
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088880/
https://www.ncbi.nlm.nih.gov/pubmed/33977256
http://dx.doi.org/10.1002/iju5.12279
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