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First case of ductal adenocarcinoma of the prostate with MAP3K1 homozygous deletion

INTRODUCTION: Ductal adenocarcinoma of the prostate is a rare prostate cancer variant and associated with higher stage and greater risk of mortality. Optimal systemic therapy for metastatic ductal adenocarcinoma is not known. CASE PRESENTATION: A 67‐year‐old man presented with ductal adenocarcinoma...

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Autores principales: Shojo, Kazunori, Kosaka, Takeo, Nakamura, Kohei, Hongo, Hiroshi, Kobayashi, Hiroaki, Mikami, Shuji, Nishihara, Hiroshi, Oya, Mototsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088887/
https://www.ncbi.nlm.nih.gov/pubmed/33977253
http://dx.doi.org/10.1002/iju5.12274
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author Shojo, Kazunori
Kosaka, Takeo
Nakamura, Kohei
Hongo, Hiroshi
Kobayashi, Hiroaki
Mikami, Shuji
Nishihara, Hiroshi
Oya, Mototsugu
author_facet Shojo, Kazunori
Kosaka, Takeo
Nakamura, Kohei
Hongo, Hiroshi
Kobayashi, Hiroaki
Mikami, Shuji
Nishihara, Hiroshi
Oya, Mototsugu
author_sort Shojo, Kazunori
collection PubMed
description INTRODUCTION: Ductal adenocarcinoma of the prostate is a rare prostate cancer variant and associated with higher stage and greater risk of mortality. Optimal systemic therapy for metastatic ductal adenocarcinoma is not known. CASE PRESENTATION: A 67‐year‐old man presented with ductal adenocarcinoma of the prostate accompanied by multiple lung metastases and advanced bone metastases. We performed channel transurethral resection of the prostate and confirmed the diagnosis of ductal adenocarcinoma of the prostate. DNA sequencing identified a TP53 somatic point mutation (p.Gly245Ser) as the pathogenic variant. Furthermore, a homozygous deletion was observed in mitogen‐activated protein kinase kinase kinase 1. The patient received enzalutamide but deceased 5 months after presenting to our institution. CONCLUSION: To our knowledge, this is the first report of ductal adenocarcinoma of the prostate with a mitogen‐activated protein kinase kinase kinase 1 homozygous deletion. Accumulation of whole‐exome sequencing data is expected to inform future advances in therapy development.
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spelling pubmed-80888872021-05-10 First case of ductal adenocarcinoma of the prostate with MAP3K1 homozygous deletion Shojo, Kazunori Kosaka, Takeo Nakamura, Kohei Hongo, Hiroshi Kobayashi, Hiroaki Mikami, Shuji Nishihara, Hiroshi Oya, Mototsugu IJU Case Rep Case Reports INTRODUCTION: Ductal adenocarcinoma of the prostate is a rare prostate cancer variant and associated with higher stage and greater risk of mortality. Optimal systemic therapy for metastatic ductal adenocarcinoma is not known. CASE PRESENTATION: A 67‐year‐old man presented with ductal adenocarcinoma of the prostate accompanied by multiple lung metastases and advanced bone metastases. We performed channel transurethral resection of the prostate and confirmed the diagnosis of ductal adenocarcinoma of the prostate. DNA sequencing identified a TP53 somatic point mutation (p.Gly245Ser) as the pathogenic variant. Furthermore, a homozygous deletion was observed in mitogen‐activated protein kinase kinase kinase 1. The patient received enzalutamide but deceased 5 months after presenting to our institution. CONCLUSION: To our knowledge, this is the first report of ductal adenocarcinoma of the prostate with a mitogen‐activated protein kinase kinase kinase 1 homozygous deletion. Accumulation of whole‐exome sequencing data is expected to inform future advances in therapy development. John Wiley and Sons Inc. 2021-03-17 /pmc/articles/PMC8088887/ /pubmed/33977253 http://dx.doi.org/10.1002/iju5.12274 Text en © 2021 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Shojo, Kazunori
Kosaka, Takeo
Nakamura, Kohei
Hongo, Hiroshi
Kobayashi, Hiroaki
Mikami, Shuji
Nishihara, Hiroshi
Oya, Mototsugu
First case of ductal adenocarcinoma of the prostate with MAP3K1 homozygous deletion
title First case of ductal adenocarcinoma of the prostate with MAP3K1 homozygous deletion
title_full First case of ductal adenocarcinoma of the prostate with MAP3K1 homozygous deletion
title_fullStr First case of ductal adenocarcinoma of the prostate with MAP3K1 homozygous deletion
title_full_unstemmed First case of ductal adenocarcinoma of the prostate with MAP3K1 homozygous deletion
title_short First case of ductal adenocarcinoma of the prostate with MAP3K1 homozygous deletion
title_sort first case of ductal adenocarcinoma of the prostate with map3k1 homozygous deletion
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088887/
https://www.ncbi.nlm.nih.gov/pubmed/33977253
http://dx.doi.org/10.1002/iju5.12274
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