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Oncogenic KRAS–expressing organoids with biliary epithelial stem cell properties give rise to biliary tract cancer in mice

Biliary tract cancer (BTC) arises from biliary epithelial cells (BECs) and includes intrahepatic cholangiocarcinoma (IHCC), gallbladder cancer (GC), and extrahepatic cholangiocarcinoma (EHCC). Although frequent KRAS mutations and epigenetic changes at the INK4A/ARF locus have been identified, the mo...

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Detalles Bibliográficos
Autores principales:	Kasuga, Akiyoshi, Semba, Takashi, Sato, Ryo, Nobusue, Hiroyuki, Sugihara, Eiji, Takaishi, Hiromasa, Kanai, Takanori, Saya, Hideyuki, Arima, Yoshimi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088913/ https://www.ncbi.nlm.nih.gov/pubmed/33068050 http://dx.doi.org/10.1111/cas.14703

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