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Long‐term antihypertensive drug use and risk of cancer: The Japan Public Health Center‐based prospective study
Antihypertensive drugs have been reported as both promotors and suppressors of cancers and this relationship has been known for several decades. We examined a large‐scale prospective cohort study in Japan to assess the relationship between long‐term antihypertensive drug use, for 10 y, and carcinoge...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088916/ https://www.ncbi.nlm.nih.gov/pubmed/33660381 http://dx.doi.org/10.1111/cas.14870 |
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author | Matsui, Satoshi Sobue, Tomotaka Zha, Ling Kitamura, Tetsuhisa Sawada, Norie Iwasaki, Motoki Shimazu, Taichi Tsugane, Shoichiro |
author_facet | Matsui, Satoshi Sobue, Tomotaka Zha, Ling Kitamura, Tetsuhisa Sawada, Norie Iwasaki, Motoki Shimazu, Taichi Tsugane, Shoichiro |
author_sort | Matsui, Satoshi |
collection | PubMed |
description | Antihypertensive drugs have been reported as both promotors and suppressors of cancers and this relationship has been known for several decades. We examined a large‐scale prospective cohort study in Japan to assess the relationship between long‐term antihypertensive drug use, for 10 y, and carcinogenesis. We divided participants into 4 categories according to the period of antihypertensive drug use, and calculated the hazard ratios (HRs), 95% confidence intervals (CIs), and P trends using the Cox proportional hazard model. In all cancers, there was a significant difference in the medication period and the adjusted HR, as well as a significant difference in the P trend. Furthermore, more than 10 y use of antihypertensive drugs significantly increased the adjusted HR in colorectal cancer (multivariable HR: 1.18, 95% CI: 1.01‐1.37 in the >10 y use group; P for trend = .033) and renal cancer (multivariable HR: 3.76, 95% CI: 2.32‐6.10 in the 5‐10 y use group; multivariable HR: 2.14, 95% CI: 1.29‐3.56 in the >10 y use group; P for trend < .001). The highest adjusted HR in renal cancer among antihypertensive drug users was observed in the analysis performed on patients in which the outcomes were calculated from 3 y after the 10‐y follow‐up survey and by sex. A large‐scale cohort study in Japan suggested that long‐term use of antihypertensive drugs may be associated with an increased incidence of colorectal and renal cancer. |
format | Online Article Text |
id | pubmed-8088916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80889162021-05-10 Long‐term antihypertensive drug use and risk of cancer: The Japan Public Health Center‐based prospective study Matsui, Satoshi Sobue, Tomotaka Zha, Ling Kitamura, Tetsuhisa Sawada, Norie Iwasaki, Motoki Shimazu, Taichi Tsugane, Shoichiro Cancer Sci Original Articles Antihypertensive drugs have been reported as both promotors and suppressors of cancers and this relationship has been known for several decades. We examined a large‐scale prospective cohort study in Japan to assess the relationship between long‐term antihypertensive drug use, for 10 y, and carcinogenesis. We divided participants into 4 categories according to the period of antihypertensive drug use, and calculated the hazard ratios (HRs), 95% confidence intervals (CIs), and P trends using the Cox proportional hazard model. In all cancers, there was a significant difference in the medication period and the adjusted HR, as well as a significant difference in the P trend. Furthermore, more than 10 y use of antihypertensive drugs significantly increased the adjusted HR in colorectal cancer (multivariable HR: 1.18, 95% CI: 1.01‐1.37 in the >10 y use group; P for trend = .033) and renal cancer (multivariable HR: 3.76, 95% CI: 2.32‐6.10 in the 5‐10 y use group; multivariable HR: 2.14, 95% CI: 1.29‐3.56 in the >10 y use group; P for trend < .001). The highest adjusted HR in renal cancer among antihypertensive drug users was observed in the analysis performed on patients in which the outcomes were calculated from 3 y after the 10‐y follow‐up survey and by sex. A large‐scale cohort study in Japan suggested that long‐term use of antihypertensive drugs may be associated with an increased incidence of colorectal and renal cancer. John Wiley and Sons Inc. 2021-04-01 2021-05 /pmc/articles/PMC8088916/ /pubmed/33660381 http://dx.doi.org/10.1111/cas.14870 Text en © 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Matsui, Satoshi Sobue, Tomotaka Zha, Ling Kitamura, Tetsuhisa Sawada, Norie Iwasaki, Motoki Shimazu, Taichi Tsugane, Shoichiro Long‐term antihypertensive drug use and risk of cancer: The Japan Public Health Center‐based prospective study |
title | Long‐term antihypertensive drug use and risk of cancer: The Japan Public Health Center‐based prospective study |
title_full | Long‐term antihypertensive drug use and risk of cancer: The Japan Public Health Center‐based prospective study |
title_fullStr | Long‐term antihypertensive drug use and risk of cancer: The Japan Public Health Center‐based prospective study |
title_full_unstemmed | Long‐term antihypertensive drug use and risk of cancer: The Japan Public Health Center‐based prospective study |
title_short | Long‐term antihypertensive drug use and risk of cancer: The Japan Public Health Center‐based prospective study |
title_sort | long‐term antihypertensive drug use and risk of cancer: the japan public health center‐based prospective study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088916/ https://www.ncbi.nlm.nih.gov/pubmed/33660381 http://dx.doi.org/10.1111/cas.14870 |
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