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Mispair-bound human MutS–MutL complex triggers DNA incisions and activates mismatch repair

DNA mismatch repair (MMR) relies on MutS and MutL ATPases for mismatch recognition and strand-specific nuclease recruitment to remove mispaired bases in daughter strands. However, whether the MutS–MutL complex coordinates MMR by ATP-dependent sliding on DNA or protein–protein interactions between th...

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Detalles Bibliográficos
Autores principales:	Ortega, Janice, Lee, Grace Sanghee, Gu, Liya, Yang, Wei, Li, Guo-Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089094/ https://www.ncbi.nlm.nih.gov/pubmed/33510387 http://dx.doi.org/10.1038/s41422-021-00468-y

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