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Prevalence and Timing of Tracheostomy and Its Impact on Clinical Outcomes in COVID-19 Pneumonia Patients in Dubai Hospital

INTRODUCTION: Coronavirus has caused more than a million deaths as of October 2020. Hospitals consider tracheostomy after the patient is virus negative, usually after 3 weeks. Prevalence and timing of tracheostomy and its impact on survival among COVID patients are unknown. METHODS: A retrospective,...

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Autores principales: Nadeem, Rashid, Zahra, Ahmed Najah, Hassan, Mustafa, Parvez, Yusuf, Gundawar, Nilesh, Hussein, Mohammed A.M., Younis, Manal, Mathews, Manoj P., Khan, Wasim, Saleh, Majid Ahmed, Mumtaz, Imran, Aljaghoub, Hebah Rami, Elfatih, Ahd, Waleed, Alaa, Ghoneem, Alaa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089406/
http://dx.doi.org/10.1159/000515209
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author Nadeem, Rashid
Zahra, Ahmed Najah
Hassan, Mustafa
Parvez, Yusuf
Gundawar, Nilesh
Hussein, Mohammed A.M.
Younis, Manal
Mathews, Manoj P.
Khan, Wasim
Saleh, Majid Ahmed
Mumtaz, Imran
Aljaghoub, Hebah Rami
Elfatih, Ahd
Waleed, Alaa
Ghoneem, Alaa
author_facet Nadeem, Rashid
Zahra, Ahmed Najah
Hassan, Mustafa
Parvez, Yusuf
Gundawar, Nilesh
Hussein, Mohammed A.M.
Younis, Manal
Mathews, Manoj P.
Khan, Wasim
Saleh, Majid Ahmed
Mumtaz, Imran
Aljaghoub, Hebah Rami
Elfatih, Ahd
Waleed, Alaa
Ghoneem, Alaa
author_sort Nadeem, Rashid
collection PubMed
description INTRODUCTION: Coronavirus has caused more than a million deaths as of October 2020. Hospitals consider tracheostomy after the patient is virus negative, usually after 3 weeks. Prevalence and timing of tracheostomy and its impact on survival among COVID patients are unknown. METHODS: A retrospective, single-center study of all patients with COVID-19 ARDS who underwent tracheostomy was conducted. Patients with age <18 and patients treated with ECMO were excluded. Duration of ventilation before tracheostomy was recorded. Clinical variables, outcome variables, and confounding variables were recorded and compared between patients with tracheostomy and without tracheostomy. The aim was to determine prevalence and timing of tracheostomy and its impact on clinical outcomes. RESULTS: We found that tracheostomies were performed only in 21 out of 196 patients (10.8%). Tracheostomies were performed after 3 weeks on average (22.1 ± 7.5 days). Survival was significantly higher in patients who underwent tracheostomy (85.7 vs. 42.5%, p = 0.001). LOSICU was longer for tracheostomy patients than patients without tracheostomy (median [IQR]: 35 [23–47] vs. 15 [9–21], p = 0.001). Patients who underwent tracheostomy had a higher proportion of treatment with continuous renal replacement therapy (CRRT) (52 vs. 30%, p = 0.04), more COVID-19 swab testing (6.5 [4.5–8.5] vs. 5 [3–7], p = 0.002), more days on mechanical ventilation (34.5 [24–45] vs. 11 [5.5–16.5], p = 0.001), and more length of stay in the hospital (54 [38–70] vs. 20 [10.5–29.5], p = 0.001). All other factors were not statistically different between the 2 groups. Approximately 29% of patients had possible false-negative testing as their swab became positive after being negative. CONCLUSION: Tracheostomy was performed only in 10% of our patients with COVID-19 ARDS. Time to tracheostomy was after 3 weeks on average. Survival was better in patients with tracheostomy, but tracheostomized patients stayed longer in the ICU and hospital and utilized more days of mechanical ventilation and CRRT.
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spelling pubmed-80894062021-05-03 Prevalence and Timing of Tracheostomy and Its Impact on Clinical Outcomes in COVID-19 Pneumonia Patients in Dubai Hospital Nadeem, Rashid Zahra, Ahmed Najah Hassan, Mustafa Parvez, Yusuf Gundawar, Nilesh Hussein, Mohammed A.M. Younis, Manal Mathews, Manoj P. Khan, Wasim Saleh, Majid Ahmed Mumtaz, Imran Aljaghoub, Hebah Rami Elfatih, Ahd Waleed, Alaa Ghoneem, Alaa Dubai Medical Journal Educational Corner − Research Article INTRODUCTION: Coronavirus has caused more than a million deaths as of October 2020. Hospitals consider tracheostomy after the patient is virus negative, usually after 3 weeks. Prevalence and timing of tracheostomy and its impact on survival among COVID patients are unknown. METHODS: A retrospective, single-center study of all patients with COVID-19 ARDS who underwent tracheostomy was conducted. Patients with age <18 and patients treated with ECMO were excluded. Duration of ventilation before tracheostomy was recorded. Clinical variables, outcome variables, and confounding variables were recorded and compared between patients with tracheostomy and without tracheostomy. The aim was to determine prevalence and timing of tracheostomy and its impact on clinical outcomes. RESULTS: We found that tracheostomies were performed only in 21 out of 196 patients (10.8%). Tracheostomies were performed after 3 weeks on average (22.1 ± 7.5 days). Survival was significantly higher in patients who underwent tracheostomy (85.7 vs. 42.5%, p = 0.001). LOSICU was longer for tracheostomy patients than patients without tracheostomy (median [IQR]: 35 [23–47] vs. 15 [9–21], p = 0.001). Patients who underwent tracheostomy had a higher proportion of treatment with continuous renal replacement therapy (CRRT) (52 vs. 30%, p = 0.04), more COVID-19 swab testing (6.5 [4.5–8.5] vs. 5 [3–7], p = 0.002), more days on mechanical ventilation (34.5 [24–45] vs. 11 [5.5–16.5], p = 0.001), and more length of stay in the hospital (54 [38–70] vs. 20 [10.5–29.5], p = 0.001). All other factors were not statistically different between the 2 groups. Approximately 29% of patients had possible false-negative testing as their swab became positive after being negative. CONCLUSION: Tracheostomy was performed only in 10% of our patients with COVID-19 ARDS. Time to tracheostomy was after 3 weeks on average. Survival was better in patients with tracheostomy, but tracheostomized patients stayed longer in the ICU and hospital and utilized more days of mechanical ventilation and CRRT. S. Karger AG 2021-04-14 /pmc/articles/PMC8089406/ http://dx.doi.org/10.1159/000515209 Text en Copyright © 2021 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
spellingShingle Educational Corner − Research Article
Nadeem, Rashid
Zahra, Ahmed Najah
Hassan, Mustafa
Parvez, Yusuf
Gundawar, Nilesh
Hussein, Mohammed A.M.
Younis, Manal
Mathews, Manoj P.
Khan, Wasim
Saleh, Majid Ahmed
Mumtaz, Imran
Aljaghoub, Hebah Rami
Elfatih, Ahd
Waleed, Alaa
Ghoneem, Alaa
Prevalence and Timing of Tracheostomy and Its Impact on Clinical Outcomes in COVID-19 Pneumonia Patients in Dubai Hospital
title Prevalence and Timing of Tracheostomy and Its Impact on Clinical Outcomes in COVID-19 Pneumonia Patients in Dubai Hospital
title_full Prevalence and Timing of Tracheostomy and Its Impact on Clinical Outcomes in COVID-19 Pneumonia Patients in Dubai Hospital
title_fullStr Prevalence and Timing of Tracheostomy and Its Impact on Clinical Outcomes in COVID-19 Pneumonia Patients in Dubai Hospital
title_full_unstemmed Prevalence and Timing of Tracheostomy and Its Impact on Clinical Outcomes in COVID-19 Pneumonia Patients in Dubai Hospital
title_short Prevalence and Timing of Tracheostomy and Its Impact on Clinical Outcomes in COVID-19 Pneumonia Patients in Dubai Hospital
title_sort prevalence and timing of tracheostomy and its impact on clinical outcomes in covid-19 pneumonia patients in dubai hospital
topic Educational Corner − Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089406/
http://dx.doi.org/10.1159/000515209
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