Cargando…

Androgen Receptor Highjacks ErbB-2 Nuclear Function to Induce Triple Negative Breast Cancer Growth

Triple negative breast cancer (TNBC) has poor prognosis and neither established biomarkers nor therapeutic targets. On the one hand the androgen receptor (AR), a steroid hormone receptor (SR) which is expressed in 10-53% of TNBC and proved to be critical for BC proliferation, has been proposed as a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deamicis, Agustina Roldán, Oakley, Robert H, Helguera, Sergio Andonegui, Lenze, Mariela B, Madera, Santiago, Russo, Rosalia I Cordo, Chervo, María F, Schillaci, Roxana, Fresno, Cristóbal, Cidlowski, John A, Elizalde, Patricia V, Proietti, Cecilia J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Steroid Hormones and Receptors
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089663/ http://dx.doi.org/10.1210/jendso/bvab048.1635

Ejemplares similares

ODP441 NErbB-2 and Androgen Receptor Regulate a Gene Signature Involved in Immune Response and Favorable Outcome in TNBC
por: Elizalde, Patricia, et al.
Publicado: (2022)

ODP438 Canonical and Non-canonical Function of EZH2 in Progesterone Receptor Target Genes in Breast Cancer
por: Elizalde, Patricia, et al.
Publicado: (2022)

OR12-02 When the Glucocorticoid Receptor Meets the Mineralocorticoid Receptor in the Nucleus of Human Cells
por: Petrillo, Maria G, et al.
Publicado: (2020)

SAT-005 Gene Expression and Behavioral Alterations in Mice with Conditional Knockout of GR, MR, or Both GR and MR in the Hippocampus
por: Oakley, Robert, et al.
Publicado: (2019)

One Hormone for Two Receptors: Exploring Glucocorticoid Actions Mediated by the Glucocorticoid and Mineralocorticoid Receptors
por: Petrillo, Maria G, et al.
Publicado: (2021)

Halting Retrograde Transport Excludes ErbB-2 From the Nucleus Abrogating Tumor Growth in Triple Negative Breast Cancer
por: Madera, Santiago, et al.
Publicado: (2021)

SAT-008 Overcoming BCL-2 Resistance in Glucocorticoid-Treated Tumor Lymphoid Cells
por: Bortner, Carl, et al.
Publicado: (2019)

Glucocorticoid Mediated Transcriptional Activity in Human Corneal Epithelial Cells Lacking the Glucocorticoid Receptor
por: Jonsson, Andrea Joyce, et al.
Publicado: (2021)

SUN-737 Induction of the Pro-Diabetic Gene DPP4 by Glucocorticoids: New Evidence of Pro-Inflammatory Effects in Macrophages
por: Diaz-Jimenez, David, et al.
Publicado: (2020)

The Impact of a Single Phosphorylation Site Mutation in the Glucocorticoid Receptor on the Molecular and Cellular Development of the Cerebral Cortex
por: Gupta, Herschel Raj, et al.
Publicado: (2021)

SUN-008 The Glucocorticoid Receptor Is Essential For TGFβ and p38 MAPK Mediated Cancer Phenotypes in Triple Negative Breast Cancer
por: Perez Kerkvliet, Carlos, et al.
Publicado: (2019)

Nuclear ErbB-2-Induced Transcriptome Drives Triple Negative Breast Cancer Growth
por: Chervo, Maria F, et al.
Publicado: (2021)

Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer
por: Madera, Santiago, et al.
Publicado: (2022)

SAT-LB002 Steroid Metabolome Analysis Reveals 11-Ketotestosterone as the Most Abundant Androgen in Castration-Resistant Prostate Cancer Patients on Second-Line Therapies
por: Snaterse, Gido, et al.
Publicado: (2019)

SAT-LB001 Traditional Sex Steroids and Ketoandrogen Levels by Menstrual Cycle Stage, Age and Body Mass Index in Women Aged 18-39 Years
por: Skiba, Marina, et al.
Publicado: (2019)

SAT-001 Supra-Physiological Testosterone Treatment Reduces Aortic Atheroma but Increases Markers of Cardiac Hypertrophy
por: Kelly, Daniel, et al.
Publicado: (2019)

SAT-023 Cyclic Regulation of 11 Beta-Hydroxysteroid Dehydrogenase Type 1 in Endometriosis in Rhesus Macaques
por: Slayden, Ov, et al.
Publicado: (2019)

SAT-021 Efficacy of Vitamin D Supplementation According to Vitamin D Binding Protein Polymorphisms
por: Al-Daghri, Nasser, et al.
Publicado: (2019)

SAT-016 The Influence of Aldosterone Values in the Tributary Veins of Unresected Adrenal Gland on Primary Aldosteronism Surgical Outcomes
por: Nakai, Kazuki, et al.
Publicado: (2019)

SAT-012 Urinary Aldosterone Assay Using LC-MS/MS Could Improve Primary Aldosteronism Screening
por: Travers, Simon, et al.
Publicado: (2019)

SAT-003 Therapeutic Glucocorticoids Prevent Local and Systemic Bone Loss but Exacerbate Muscle Wasting When Administered in Chronic Inflammation
por: Fenton, Chloe, et al.
Publicado: (2019)

SAT-014 No Correlation between Serum Testosterone Levels and Aggression or Anger Intensity in Transgender People: Results from Five European Centres
por: Defreyne, Justine, et al.
Publicado: (2019)

SAT-006 Dihydrotestosterone (DHT) Enhances Major Burn Injury Wound Healing by Regulating the Inflammatory Response in Mice
por: Shi, Huaikai, et al.
Publicado: (2019)

SUN-LB001 Estetrol (E4) Is a Unique Estrogen with Selective Actions in Tissues Which Are Distinctly Different from the Actions of SERMs
por: Foidart, Jean-Michel, et al.
Publicado: (2019)

SAT-015 Gender Differences in the Association between Sex Hormones and Hyperuricemia in Patients with Type 2 Diabetes
por: Wan, Heng, et al.
Publicado: (2019)

OR09-2 Pathway Preferential Estrogens Prevent Hepatosteatosis Due to Ovariectomy and High-Fat Diets
por: Zuo, Qianying, et al.
Publicado: (2019)

OR26-3 ERK1/2-RSK2 Maintains Estrogen Homeostasis in the Adult Mammary Gland
por: Sandusky, Zachary
Publicado: (2019)

OR26-1 Phosphorylated Progesterone Receptor Isoforms Mediate Opposing Stem-Like and Proliferative Breast Cancer Cell Fates
por: Truong, Thu, et al.
Publicado: (2019)

OR09-1 Estrogen Drives Atypical Cell-autonomous WNT4 Signaling In Lobular Carcinoma
por: Ferguson, Rebecca, et al.
Publicado: (2019)

OR26-5 Functional Analysis of Estrogen-Regulated Enhancer RNAs in Breast Cancer Cells
por: Hou, Tim, et al.
Publicado: (2019)

OR09-6 Selective and Durable Suppression of Aldosterone Production in Non-Human Primates by a Novel Aldosterone Synthase Inhibitor
por: Sparks, Steven, et al.
Publicado: (2019)

OR26-4 Genome-Wide Binding Profile of Phosphorylated Estrogen Receptor Reveals Association with Direct DNA Binding
por: Helzer, Kyle, et al.
Publicado: (2019)

OR09-3 11β-HSD1 Mediates a Partial Suppression of Muscle Atrophy in Chronic Inflammatory Disease in Response to Therapeutic Glucocorticoids
por: Webster, Justine, et al.
Publicado: (2019)

OR26-2 Phosphorylation of Estrogen Receptor Alpha is Required for Mammary Gland Development and MCF-7 Breast Tumor Response to Estradiol and Tamoxifen
por: Emneser, Waleed, et al.
Publicado: (2019)

OR26-6 Glucocorticoid Receptor Quaternary Structure Drives Chromatin Occupancy and Transcriptional Outcome
por: Paakinaho, Ville, et al.
Publicado: (2019)

OR09-4 Estrogen Sulfotransferase (EST) as a Mediator of Ischemic Acute Kidney Injury in Mice
por: Barbosa, Anne, et al.
Publicado: (2019)

OR09-5 Importance of Islet Intracrinology for Glucose-Stimulated Insulin Secretion (GSIS) in the Male
por: Xu, Weiwei, et al.
Publicado: (2019)

SUN-018 Epigenetic Loss of the PIWI/piRNA Machinery in Gonadal Tumors in Androgen Insensitivity Syndrome
por: Batista, Rafael, et al.
Publicado: (2019)

SUN-002 Control of Metastasis by DAX-1 in Prostate Cancer Cells, an Androgen-Induced Orphan Nuclear Receptor
por: Beltran, Roxxana, et al.
Publicado: (2019)

SUN-025 Thyroid Hormone Suppresses FOXM1 Expression to Reduce Liver Cancer Progression
por: Lin, Kwang-Huei, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_tg6u27b914qr7lm6037q3jqdbu