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Changes in Adrenal and Gonadal Androgens After 14-Day Treatment With CRF1 Receptor Antagonist, Crinecerfont (NBI-74788), in Men With Classic 21-Hydroxylase Deficiency

Background: Congenital adrenal hyperplasia due to classic 21-hydroxylase deficiency (21OHD) causes cortisol insufficiency and androgen excess. A phase 2 trial of crinecerfont, a CRF1 receptor antagonist, in 18 adults with 21OHD showed prominent decreases in ACTH, 17-hydroxyprogesterone, and androste...

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Detalles Bibliográficos
Autores principales:	He, Xin, Sarafoglou, Kyriakie, Fechner, Patricia Y, Vogiatzi, Maria George, Imel, Erik Allen, Davis, Shanlee Marie, Sturgeon, Julia, Chan, Jean Lin, Farber, Robert, Auchus, Richard Joseph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Adrenal
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089669/ http://dx.doi.org/10.1210/jendso/bvab048.157

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