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Impact of Hypertriglyceridemia on Outcome of Adult Patient Admitted With Hyperthyroidism: Analysis of the National Inpatient Sample 2016–2017

Introduction: Thyroid dysfunction has a great impact on lipids as well as a number of other cardiovascular risk factors. Though the effect of thyroid hormones on plasma cholesterol concentrations are well-recognized, however, there are conflicting reports about the effect of thyroid hormone on the m...

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Autores principales: Asemota, Iriagbonse, Akuna, Emmanuel, Shaka, Hafeez, Edigin, Ehizogie, Velazquez, Genaro, Ojemolon, Pius, Asotibe, Jennifer Chiagoziem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089942/
http://dx.doi.org/10.1210/jendso/bvab048.587
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author Asemota, Iriagbonse
Akuna, Emmanuel
Shaka, Hafeez
Edigin, Ehizogie
Velazquez, Genaro
Ojemolon, Pius
Asotibe, Jennifer Chiagoziem
author_facet Asemota, Iriagbonse
Akuna, Emmanuel
Shaka, Hafeez
Edigin, Ehizogie
Velazquez, Genaro
Ojemolon, Pius
Asotibe, Jennifer Chiagoziem
author_sort Asemota, Iriagbonse
collection PubMed
description Introduction: Thyroid dysfunction has a great impact on lipids as well as a number of other cardiovascular risk factors. Though the effect of thyroid hormones on plasma cholesterol concentrations are well-recognized, however, there are conflicting reports about the effect of thyroid hormone on the metabolism of plasma triglycerides. We sought to determine the effect of hypertriglyceridemia on patient admitted with hyperthyroidism. Methods: We queried the National Inpatient Sample (NIS) databases from 2016 to 2017 for adults aged 18 and above with hypertriglyceridemia as a principle diagnosis with and without hyperthyroidism using ICD-10 codes. Multivariate logistic and linear regression analysis was used accordingly to adjust for confounders. Results: There were over 71 million discharges in the combined 2016 and 2017 NIS database. Out of 17,705 hyperthyroidism hospitalizations, 15% had hypertriglyceridemia. Hypertriglyceridemia with hyperthyroidism had a similar odds of inpatient mortality (AOR 0.37, CI 0.06–1.99, P=0.246), acute kidney injury (AOR 1.03, CI 0.706–1.510, P=0.868) and cardiogenic shock (AOR 0.96, CI 0.134–6.72, P=0.963). There was a statistically significant increase in odds of acute respiratory failure (AOR 0.46, CI- 0.21- 0.99, P=0.048) in those hospitalized with hyperthyroidism and hypertriglyceridemia compared to those with hyperthyroidism alone. Conclusion: Hypertriglyceridemia is associated with similar outcomes in patient admitted for hyperthyroidism in terms of mortality, acute kidney injury and acute cardiogenic shock with an increased odd of acute respiratory failure. More research is needed to explain the pathophysiologic mechanism underlying the effect of hypertriglyceridemia on hyperthyroidism.
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spelling pubmed-80899422021-05-06 Impact of Hypertriglyceridemia on Outcome of Adult Patient Admitted With Hyperthyroidism: Analysis of the National Inpatient Sample 2016–2017 Asemota, Iriagbonse Akuna, Emmanuel Shaka, Hafeez Edigin, Ehizogie Velazquez, Genaro Ojemolon, Pius Asotibe, Jennifer Chiagoziem J Endocr Soc Cardiovascular Endocrinology Introduction: Thyroid dysfunction has a great impact on lipids as well as a number of other cardiovascular risk factors. Though the effect of thyroid hormones on plasma cholesterol concentrations are well-recognized, however, there are conflicting reports about the effect of thyroid hormone on the metabolism of plasma triglycerides. We sought to determine the effect of hypertriglyceridemia on patient admitted with hyperthyroidism. Methods: We queried the National Inpatient Sample (NIS) databases from 2016 to 2017 for adults aged 18 and above with hypertriglyceridemia as a principle diagnosis with and without hyperthyroidism using ICD-10 codes. Multivariate logistic and linear regression analysis was used accordingly to adjust for confounders. Results: There were over 71 million discharges in the combined 2016 and 2017 NIS database. Out of 17,705 hyperthyroidism hospitalizations, 15% had hypertriglyceridemia. Hypertriglyceridemia with hyperthyroidism had a similar odds of inpatient mortality (AOR 0.37, CI 0.06–1.99, P=0.246), acute kidney injury (AOR 1.03, CI 0.706–1.510, P=0.868) and cardiogenic shock (AOR 0.96, CI 0.134–6.72, P=0.963). There was a statistically significant increase in odds of acute respiratory failure (AOR 0.46, CI- 0.21- 0.99, P=0.048) in those hospitalized with hyperthyroidism and hypertriglyceridemia compared to those with hyperthyroidism alone. Conclusion: Hypertriglyceridemia is associated with similar outcomes in patient admitted for hyperthyroidism in terms of mortality, acute kidney injury and acute cardiogenic shock with an increased odd of acute respiratory failure. More research is needed to explain the pathophysiologic mechanism underlying the effect of hypertriglyceridemia on hyperthyroidism. Oxford University Press 2021-05-03 /pmc/articles/PMC8089942/ http://dx.doi.org/10.1210/jendso/bvab048.587 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Cardiovascular Endocrinology
Asemota, Iriagbonse
Akuna, Emmanuel
Shaka, Hafeez
Edigin, Ehizogie
Velazquez, Genaro
Ojemolon, Pius
Asotibe, Jennifer Chiagoziem
Impact of Hypertriglyceridemia on Outcome of Adult Patient Admitted With Hyperthyroidism: Analysis of the National Inpatient Sample 2016–2017
title Impact of Hypertriglyceridemia on Outcome of Adult Patient Admitted With Hyperthyroidism: Analysis of the National Inpatient Sample 2016–2017
title_full Impact of Hypertriglyceridemia on Outcome of Adult Patient Admitted With Hyperthyroidism: Analysis of the National Inpatient Sample 2016–2017
title_fullStr Impact of Hypertriglyceridemia on Outcome of Adult Patient Admitted With Hyperthyroidism: Analysis of the National Inpatient Sample 2016–2017
title_full_unstemmed Impact of Hypertriglyceridemia on Outcome of Adult Patient Admitted With Hyperthyroidism: Analysis of the National Inpatient Sample 2016–2017
title_short Impact of Hypertriglyceridemia on Outcome of Adult Patient Admitted With Hyperthyroidism: Analysis of the National Inpatient Sample 2016–2017
title_sort impact of hypertriglyceridemia on outcome of adult patient admitted with hyperthyroidism: analysis of the national inpatient sample 2016–2017
topic Cardiovascular Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8089942/
http://dx.doi.org/10.1210/jendso/bvab048.587
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