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Carbonyl Reductase 1 Overexpression in Adipose Amplifies Local Glucocorticoid Action and Impairs Glucose Tolerance in Lean Mice

Glucocorticoids play a critical role in metabolic homeostasis. Chronic or excessive activation of the glucocorticoid receptor (GR) in adipose tissue contributes to metabolic disorders such as glucose intolerance and insulin resistance. Steroid-metabolising enzymes in adipose, such as 11β-HSD1 or 5α-...

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Detalles Bibliográficos
Autores principales:	Bell, Rachel, Villalobos, Elisa, Nixon, Mark, Miguelez-Crespo, Allende, Sharp, Matthew, Koerner, Martha, Allan, Emma, Denham, Scott, Lee, Patricia, Homer, Natalie, Walker, Brian, Morgan, Ruth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Steroid Hormones and Receptors
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8090251/ http://dx.doi.org/10.1210/jendso/bvab048.1639

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