Cargando…
High incidence of stroke and mortality in pediatric critical care patients with COVID-19 in Peru
INTRODUCTION: Pediatric critical care patients with COVID-19 treated in Peru have higher mortality than those previously reported from other countries. Pediatric providers have reported a high number of patients without comorbidities presenting with hemorrhagic strokes associated with COVID-19. We p...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8090521/ https://www.ncbi.nlm.nih.gov/pubmed/33941862 http://dx.doi.org/10.1038/s41390-021-01547-x |
_version_ | 1783687303513767936 |
---|---|
author | Coronado Munoz, Alvaro Tasayco, Jaime Morales, Willy Moreno, Luis Zorrilla, David Stapleton, Angie Pajuelo, Patricia Reyes, Giuliana Estupiñan, Matilde Seminario, Ricardo Ortiz, Manuel Domínguez, Jesús |
author_facet | Coronado Munoz, Alvaro Tasayco, Jaime Morales, Willy Moreno, Luis Zorrilla, David Stapleton, Angie Pajuelo, Patricia Reyes, Giuliana Estupiñan, Matilde Seminario, Ricardo Ortiz, Manuel Domínguez, Jesús |
author_sort | Coronado Munoz, Alvaro |
collection | PubMed |
description | INTRODUCTION: Pediatric critical care patients with COVID-19 treated in Peru have higher mortality than those previously reported from other countries. Pediatric providers have reported a high number of patients without comorbidities presenting with hemorrhagic strokes associated with COVID-19. We present a study analyzing the factors associated with mortality in this setting. METHODS: Prospective case–control study that included patients <17 years old admitted to a pediatric critical care unit with a positive test confirming COVID-19. The primary outcome was mortality. Fisher’s exact test and the Mann–Whitney U test were used for the analysis. RESULTS: Forty-seven patients were admitted to critical care. The mortality of our study is 21.3%. The mortality of patients with neurological presentation was 45.5%, which was significantly higher than the mortality of acute COVID-19 (26.7%) and MIS-C (4.8%), p 0.18. Other risk factors for mortality in our cohort were strokes and comorbidities. Only one patient presenting with hemorrhagic stroke had an undiagnosed comorbidity. CONCLUSION: Cerebrovascular events associated with COVID-19 in pediatric patients, including infants, must be recognized as one of the more severe presentations of this infection in pediatric patients. IMPACT: Pediatric patients with COVID-19 can present with hemorrhagic and ischemic strokes on presentation. Neurological presentation in pediatric patients with COVID-19 has high mortality. Mortality of pediatric patients with COVID-19 is associated with comorbidities. Pediatric presentation and outcomes of COVID-19 in different regions can be novel to previously described. |
format | Online Article Text |
id | pubmed-8090521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group US |
record_format | MEDLINE/PubMed |
spelling | pubmed-80905212021-05-03 High incidence of stroke and mortality in pediatric critical care patients with COVID-19 in Peru Coronado Munoz, Alvaro Tasayco, Jaime Morales, Willy Moreno, Luis Zorrilla, David Stapleton, Angie Pajuelo, Patricia Reyes, Giuliana Estupiñan, Matilde Seminario, Ricardo Ortiz, Manuel Domínguez, Jesús Pediatr Res Clinical Research Article INTRODUCTION: Pediatric critical care patients with COVID-19 treated in Peru have higher mortality than those previously reported from other countries. Pediatric providers have reported a high number of patients without comorbidities presenting with hemorrhagic strokes associated with COVID-19. We present a study analyzing the factors associated with mortality in this setting. METHODS: Prospective case–control study that included patients <17 years old admitted to a pediatric critical care unit with a positive test confirming COVID-19. The primary outcome was mortality. Fisher’s exact test and the Mann–Whitney U test were used for the analysis. RESULTS: Forty-seven patients were admitted to critical care. The mortality of our study is 21.3%. The mortality of patients with neurological presentation was 45.5%, which was significantly higher than the mortality of acute COVID-19 (26.7%) and MIS-C (4.8%), p 0.18. Other risk factors for mortality in our cohort were strokes and comorbidities. Only one patient presenting with hemorrhagic stroke had an undiagnosed comorbidity. CONCLUSION: Cerebrovascular events associated with COVID-19 in pediatric patients, including infants, must be recognized as one of the more severe presentations of this infection in pediatric patients. IMPACT: Pediatric patients with COVID-19 can present with hemorrhagic and ischemic strokes on presentation. Neurological presentation in pediatric patients with COVID-19 has high mortality. Mortality of pediatric patients with COVID-19 is associated with comorbidities. Pediatric presentation and outcomes of COVID-19 in different regions can be novel to previously described. Nature Publishing Group US 2021-05-03 2022 /pmc/articles/PMC8090521/ /pubmed/33941862 http://dx.doi.org/10.1038/s41390-021-01547-x Text en © The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Clinical Research Article Coronado Munoz, Alvaro Tasayco, Jaime Morales, Willy Moreno, Luis Zorrilla, David Stapleton, Angie Pajuelo, Patricia Reyes, Giuliana Estupiñan, Matilde Seminario, Ricardo Ortiz, Manuel Domínguez, Jesús High incidence of stroke and mortality in pediatric critical care patients with COVID-19 in Peru |
title | High incidence of stroke and mortality in pediatric critical care patients with COVID-19 in Peru |
title_full | High incidence of stroke and mortality in pediatric critical care patients with COVID-19 in Peru |
title_fullStr | High incidence of stroke and mortality in pediatric critical care patients with COVID-19 in Peru |
title_full_unstemmed | High incidence of stroke and mortality in pediatric critical care patients with COVID-19 in Peru |
title_short | High incidence of stroke and mortality in pediatric critical care patients with COVID-19 in Peru |
title_sort | high incidence of stroke and mortality in pediatric critical care patients with covid-19 in peru |
topic | Clinical Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8090521/ https://www.ncbi.nlm.nih.gov/pubmed/33941862 http://dx.doi.org/10.1038/s41390-021-01547-x |
work_keys_str_mv | AT coronadomunozalvaro highincidenceofstrokeandmortalityinpediatriccriticalcarepatientswithcovid19inperu AT tasaycojaime highincidenceofstrokeandmortalityinpediatriccriticalcarepatientswithcovid19inperu AT moraleswilly highincidenceofstrokeandmortalityinpediatriccriticalcarepatientswithcovid19inperu AT morenoluis highincidenceofstrokeandmortalityinpediatriccriticalcarepatientswithcovid19inperu AT zorrilladavid highincidenceofstrokeandmortalityinpediatriccriticalcarepatientswithcovid19inperu AT stapletonangie highincidenceofstrokeandmortalityinpediatriccriticalcarepatientswithcovid19inperu AT pajuelopatricia highincidenceofstrokeandmortalityinpediatriccriticalcarepatientswithcovid19inperu AT reyesgiuliana highincidenceofstrokeandmortalityinpediatriccriticalcarepatientswithcovid19inperu AT estupinanmatilde highincidenceofstrokeandmortalityinpediatriccriticalcarepatientswithcovid19inperu AT seminarioricardo highincidenceofstrokeandmortalityinpediatriccriticalcarepatientswithcovid19inperu AT ortizmanuel highincidenceofstrokeandmortalityinpediatriccriticalcarepatientswithcovid19inperu AT dominguezjesus highincidenceofstrokeandmortalityinpediatriccriticalcarepatientswithcovid19inperu |