Cargando…
The Value of 4D Speckle-Tracking Strain Echocardiography in Evaluating the Relationship Between Asprosin and Growth Differentiation Factor-15 Levels and Subclinical Systolic Dysfunction in Patients With Acromegaly and Prolactinoma
Introduction: In patients with acromegaly and prolactinoma, the long-term presence of elevated GH and PRL levels is associated with an unfavorable cardiovascular risk profile. Early recognition of dysfunctions related to cardiovascular complications, which can be a significant contributor to mortali...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8090685/ http://dx.doi.org/10.1210/jendso/bvab048.1326 |
_version_ | 1783687342931836928 |
---|---|
author | Firlatan, Busra Karakulak, Ugur N Hekimsoy, Vedat Iremli, Burcin G Lay, Incilay Yuce, Deniz Dagdelen, Selcuk Kabakci, Giray Erbas, Tomris A |
author_facet | Firlatan, Busra Karakulak, Ugur N Hekimsoy, Vedat Iremli, Burcin G Lay, Incilay Yuce, Deniz Dagdelen, Selcuk Kabakci, Giray Erbas, Tomris A |
author_sort | Firlatan, Busra |
collection | PubMed |
description | Introduction: In patients with acromegaly and prolactinoma, the long-term presence of elevated GH and PRL levels is associated with an unfavorable cardiovascular risk profile. Early recognition of dysfunctions related to cardiovascular complications, which can be a significant contributor to mortality, is important. The aim of this study was to assess the relationship of four-dimensional speckle-tracking strain echocardiographic (4DSTE) measurements with asprosin, GDF-15 levels, and the Framingham cardiovascular risk score (FRS) in patients with acromegaly and prolactinoma. Methods: The study included 41 acromegaly [20F/21M, age: 49 (41-57)], 29 prolactinoma patients [18F/11M, age: 40 (28-48)] and 33 healthy control subjects [15F/18M, age: 48 (37-54)]. Data are presented as median with interquartile ranges (IQR). Anthropometric, biochemical and echocardiographic measurements were performed. Asprosin and GDF-15 levels were measured by ELISA. Results: Plasma asprosin concentration in the prolactinoma group [2.4 ng/mL (0.0-9.7)] was significantly lower than the concentration in both the acromegaly group [6.8 ng/mL (2.6-9.9)] and the control group [10.2 ng/mL (2.3-18.0)] (p=0.022 and p=0.006, respectively). In the study population, asprosin levels were positively correlated with age, FRS, and GDF-15 levels (r=0.361, p<0.001; r=0.275, p=0.005 and r=0.240, p=0.015; respectively). Plasma GDF-15 concentration was lower in prolactinoma group [262.2 pg/mL (169.3-336.1)] than in the acromegaly [332.5 pg/mL (257.4-438.8)] and control groups [331.3 pg/mL (233.6-428.9)] (p=0.008 and p=0.047, respectively). In multiple linear regression analysis, GDF-15 level was independently positively related to the FRS in both patient groups (p<0.001). FRS was highest in patients with acromegaly (p=0.004). In 2DE; the left ventricular ejection fraction although within normal limits, was lower in acromegaly [63% (63-65)] and prolactinoma [63% (60-65)] patients compared to the healthy controls [66% (63-68)] (p=0.003). In both acromegaly and prolactinoma groups; global longitudinal, circumferential, areal and radial strain measurements identified by 4DSTE were lower than the control group (acromegaly: p=0.007, p=0.008, p=0.015, p=0.008; prolactinoma: p=0.033, p=0.019, p=0.030, p=0.025, respectively). In contrast, diastolic functions were evaluated as normal in 85% of acromegaly patients, 86% of prolactinoma patients, and 93% of the control group (p=0.365). Conclusion: This is the first study to demonstrate the isolated subclinical systolic dysfunction identified by four-dimensional echocardiography in patients with acromegaly and prolactinoma. Asprosin may be associated with cardiovascular diseases in addition to its role in the pathogenesis of type 2 diabetes mellitus, and GDF-15 can be used as a biomarker to predict cardiovascular risk in these patient groups. |
format | Online Article Text |
id | pubmed-8090685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-80906852021-05-12 The Value of 4D Speckle-Tracking Strain Echocardiography in Evaluating the Relationship Between Asprosin and Growth Differentiation Factor-15 Levels and Subclinical Systolic Dysfunction in Patients With Acromegaly and Prolactinoma Firlatan, Busra Karakulak, Ugur N Hekimsoy, Vedat Iremli, Burcin G Lay, Incilay Yuce, Deniz Dagdelen, Selcuk Kabakci, Giray Erbas, Tomris A J Endocr Soc Neuroendocrinology and Pituitary Introduction: In patients with acromegaly and prolactinoma, the long-term presence of elevated GH and PRL levels is associated with an unfavorable cardiovascular risk profile. Early recognition of dysfunctions related to cardiovascular complications, which can be a significant contributor to mortality, is important. The aim of this study was to assess the relationship of four-dimensional speckle-tracking strain echocardiographic (4DSTE) measurements with asprosin, GDF-15 levels, and the Framingham cardiovascular risk score (FRS) in patients with acromegaly and prolactinoma. Methods: The study included 41 acromegaly [20F/21M, age: 49 (41-57)], 29 prolactinoma patients [18F/11M, age: 40 (28-48)] and 33 healthy control subjects [15F/18M, age: 48 (37-54)]. Data are presented as median with interquartile ranges (IQR). Anthropometric, biochemical and echocardiographic measurements were performed. Asprosin and GDF-15 levels were measured by ELISA. Results: Plasma asprosin concentration in the prolactinoma group [2.4 ng/mL (0.0-9.7)] was significantly lower than the concentration in both the acromegaly group [6.8 ng/mL (2.6-9.9)] and the control group [10.2 ng/mL (2.3-18.0)] (p=0.022 and p=0.006, respectively). In the study population, asprosin levels were positively correlated with age, FRS, and GDF-15 levels (r=0.361, p<0.001; r=0.275, p=0.005 and r=0.240, p=0.015; respectively). Plasma GDF-15 concentration was lower in prolactinoma group [262.2 pg/mL (169.3-336.1)] than in the acromegaly [332.5 pg/mL (257.4-438.8)] and control groups [331.3 pg/mL (233.6-428.9)] (p=0.008 and p=0.047, respectively). In multiple linear regression analysis, GDF-15 level was independently positively related to the FRS in both patient groups (p<0.001). FRS was highest in patients with acromegaly (p=0.004). In 2DE; the left ventricular ejection fraction although within normal limits, was lower in acromegaly [63% (63-65)] and prolactinoma [63% (60-65)] patients compared to the healthy controls [66% (63-68)] (p=0.003). In both acromegaly and prolactinoma groups; global longitudinal, circumferential, areal and radial strain measurements identified by 4DSTE were lower than the control group (acromegaly: p=0.007, p=0.008, p=0.015, p=0.008; prolactinoma: p=0.033, p=0.019, p=0.030, p=0.025, respectively). In contrast, diastolic functions were evaluated as normal in 85% of acromegaly patients, 86% of prolactinoma patients, and 93% of the control group (p=0.365). Conclusion: This is the first study to demonstrate the isolated subclinical systolic dysfunction identified by four-dimensional echocardiography in patients with acromegaly and prolactinoma. Asprosin may be associated with cardiovascular diseases in addition to its role in the pathogenesis of type 2 diabetes mellitus, and GDF-15 can be used as a biomarker to predict cardiovascular risk in these patient groups. Oxford University Press 2021-05-03 /pmc/articles/PMC8090685/ http://dx.doi.org/10.1210/jendso/bvab048.1326 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Neuroendocrinology and Pituitary Firlatan, Busra Karakulak, Ugur N Hekimsoy, Vedat Iremli, Burcin G Lay, Incilay Yuce, Deniz Dagdelen, Selcuk Kabakci, Giray Erbas, Tomris A The Value of 4D Speckle-Tracking Strain Echocardiography in Evaluating the Relationship Between Asprosin and Growth Differentiation Factor-15 Levels and Subclinical Systolic Dysfunction in Patients With Acromegaly and Prolactinoma |
title | The Value of 4D Speckle-Tracking Strain Echocardiography in Evaluating the Relationship Between Asprosin and Growth Differentiation Factor-15 Levels and Subclinical Systolic Dysfunction in Patients With Acromegaly and Prolactinoma |
title_full | The Value of 4D Speckle-Tracking Strain Echocardiography in Evaluating the Relationship Between Asprosin and Growth Differentiation Factor-15 Levels and Subclinical Systolic Dysfunction in Patients With Acromegaly and Prolactinoma |
title_fullStr | The Value of 4D Speckle-Tracking Strain Echocardiography in Evaluating the Relationship Between Asprosin and Growth Differentiation Factor-15 Levels and Subclinical Systolic Dysfunction in Patients With Acromegaly and Prolactinoma |
title_full_unstemmed | The Value of 4D Speckle-Tracking Strain Echocardiography in Evaluating the Relationship Between Asprosin and Growth Differentiation Factor-15 Levels and Subclinical Systolic Dysfunction in Patients With Acromegaly and Prolactinoma |
title_short | The Value of 4D Speckle-Tracking Strain Echocardiography in Evaluating the Relationship Between Asprosin and Growth Differentiation Factor-15 Levels and Subclinical Systolic Dysfunction in Patients With Acromegaly and Prolactinoma |
title_sort | value of 4d speckle-tracking strain echocardiography in evaluating the relationship between asprosin and growth differentiation factor-15 levels and subclinical systolic dysfunction in patients with acromegaly and prolactinoma |
topic | Neuroendocrinology and Pituitary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8090685/ http://dx.doi.org/10.1210/jendso/bvab048.1326 |
work_keys_str_mv | AT firlatanbusra thevalueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT karakulakugurn thevalueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT hekimsoyvedat thevalueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT iremliburcing thevalueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT layincilay thevalueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT yucedeniz thevalueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT dagdelenselcuk thevalueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT kabakcigiray thevalueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT erbastomrisa thevalueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT firlatanbusra valueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT karakulakugurn valueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT hekimsoyvedat valueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT iremliburcing valueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT layincilay valueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT yucedeniz valueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT dagdelenselcuk valueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT kabakcigiray valueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma AT erbastomrisa valueof4dspeckletrackingstrainechocardiographyinevaluatingtherelationshipbetweenasprosinandgrowthdifferentiationfactor15levelsandsubclinicalsystolicdysfunctioninpatientswithacromegalyandprolactinoma |