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Fiber ball white matter modeling in focal epilepsy

Multicompartment diffusion magnetic resonance imaging (MRI) approaches are increasingly being applied to estimate intra‐axonal and extra‐axonal diffusion characteristics in the human brain. Fiber ball imaging (FBI) and its extension fiber ball white matter modeling (FBWM) are such recently described...

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Autores principales: Bryant, Lorna, McKinnon, Emilie T., Taylor, James A., Jensen, Jens H., Bonilha, Leonardo, de Bezenac, Christophe, Kreilkamp, Barbara A. K., Adan, Guleed, Wieshmann, Udo C., Biswas, Shubhabrata, Marson, Anthony G., Keller, Simon S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8090772/
https://www.ncbi.nlm.nih.gov/pubmed/33605514
http://dx.doi.org/10.1002/hbm.25382
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author Bryant, Lorna
McKinnon, Emilie T.
Taylor, James A.
Jensen, Jens H.
Bonilha, Leonardo
de Bezenac, Christophe
Kreilkamp, Barbara A. K.
Adan, Guleed
Wieshmann, Udo C.
Biswas, Shubhabrata
Marson, Anthony G.
Keller, Simon S.
author_facet Bryant, Lorna
McKinnon, Emilie T.
Taylor, James A.
Jensen, Jens H.
Bonilha, Leonardo
de Bezenac, Christophe
Kreilkamp, Barbara A. K.
Adan, Guleed
Wieshmann, Udo C.
Biswas, Shubhabrata
Marson, Anthony G.
Keller, Simon S.
author_sort Bryant, Lorna
collection PubMed
description Multicompartment diffusion magnetic resonance imaging (MRI) approaches are increasingly being applied to estimate intra‐axonal and extra‐axonal diffusion characteristics in the human brain. Fiber ball imaging (FBI) and its extension fiber ball white matter modeling (FBWM) are such recently described multicompartment approaches. However, these particular approaches have yet to be applied in clinical cohorts. The modeling of several diffusion parameters with interpretable biological meaning may offer the development of new, noninvasive biomarkers of pharmacoresistance in epilepsy. In the present study, we used FBI and FBWM to evaluate intra‐axonal and extra‐axonal diffusion properties of white matter tracts in patients with longstanding focal epilepsy. FBI/FBWM diffusion parameters were calculated along the length of 50 white matter tract bundles and statistically compared between patients with refractory epilepsy, nonrefractory epilepsy and controls. We report that patients with chronic epilepsy had a widespread distribution of extra‐axonal diffusivity relative to controls, particularly in circumscribed regions along white matter tracts projecting to cerebral cortex from thalamic, striatal, brainstem, and peduncular regions. Patients with refractory epilepsy had significantly greater markers of extra‐axonal diffusivity compared to those with nonrefractory epilepsy. The extra‐axonal diffusivity alterations in patients with epilepsy observed in the present study could be markers of neuroinflammatory processes or a reflection of reduced axonal density, both of which have been histologically demonstrated in focal epilepsy. FBI is a clinically feasible MRI approach that provides the basis for more interpretive conclusions about the microstructural environment of the brain and may represent a unique biomarker of pharmacoresistance in epilepsy.
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spelling pubmed-80907722021-05-10 Fiber ball white matter modeling in focal epilepsy Bryant, Lorna McKinnon, Emilie T. Taylor, James A. Jensen, Jens H. Bonilha, Leonardo de Bezenac, Christophe Kreilkamp, Barbara A. K. Adan, Guleed Wieshmann, Udo C. Biswas, Shubhabrata Marson, Anthony G. Keller, Simon S. Hum Brain Mapp Research Articles Multicompartment diffusion magnetic resonance imaging (MRI) approaches are increasingly being applied to estimate intra‐axonal and extra‐axonal diffusion characteristics in the human brain. Fiber ball imaging (FBI) and its extension fiber ball white matter modeling (FBWM) are such recently described multicompartment approaches. However, these particular approaches have yet to be applied in clinical cohorts. The modeling of several diffusion parameters with interpretable biological meaning may offer the development of new, noninvasive biomarkers of pharmacoresistance in epilepsy. In the present study, we used FBI and FBWM to evaluate intra‐axonal and extra‐axonal diffusion properties of white matter tracts in patients with longstanding focal epilepsy. FBI/FBWM diffusion parameters were calculated along the length of 50 white matter tract bundles and statistically compared between patients with refractory epilepsy, nonrefractory epilepsy and controls. We report that patients with chronic epilepsy had a widespread distribution of extra‐axonal diffusivity relative to controls, particularly in circumscribed regions along white matter tracts projecting to cerebral cortex from thalamic, striatal, brainstem, and peduncular regions. Patients with refractory epilepsy had significantly greater markers of extra‐axonal diffusivity compared to those with nonrefractory epilepsy. The extra‐axonal diffusivity alterations in patients with epilepsy observed in the present study could be markers of neuroinflammatory processes or a reflection of reduced axonal density, both of which have been histologically demonstrated in focal epilepsy. FBI is a clinically feasible MRI approach that provides the basis for more interpretive conclusions about the microstructural environment of the brain and may represent a unique biomarker of pharmacoresistance in epilepsy. John Wiley & Sons, Inc. 2021-02-19 /pmc/articles/PMC8090772/ /pubmed/33605514 http://dx.doi.org/10.1002/hbm.25382 Text en © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Bryant, Lorna
McKinnon, Emilie T.
Taylor, James A.
Jensen, Jens H.
Bonilha, Leonardo
de Bezenac, Christophe
Kreilkamp, Barbara A. K.
Adan, Guleed
Wieshmann, Udo C.
Biswas, Shubhabrata
Marson, Anthony G.
Keller, Simon S.
Fiber ball white matter modeling in focal epilepsy
title Fiber ball white matter modeling in focal epilepsy
title_full Fiber ball white matter modeling in focal epilepsy
title_fullStr Fiber ball white matter modeling in focal epilepsy
title_full_unstemmed Fiber ball white matter modeling in focal epilepsy
title_short Fiber ball white matter modeling in focal epilepsy
title_sort fiber ball white matter modeling in focal epilepsy
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8090772/
https://www.ncbi.nlm.nih.gov/pubmed/33605514
http://dx.doi.org/10.1002/hbm.25382
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