Cargando…
Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review
A large body of molecular and neurophysiological evidence connects synaptic plasticity to specific functions and energy metabolism in particular areas of the brain. Furthermore, altered plasticity and energy regulation has been associated with a number of neuropsychiatric disorders. A favourable app...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8090777/ https://www.ncbi.nlm.nih.gov/pubmed/33634527 http://dx.doi.org/10.1002/hbm.25388 |
_version_ | 1783687365050499072 |
---|---|
author | Choi, Chang‐Hoon Iordanishvili, Elene Shah, N. Jon Binkofski, Ferdinand |
author_facet | Choi, Chang‐Hoon Iordanishvili, Elene Shah, N. Jon Binkofski, Ferdinand |
author_sort | Choi, Chang‐Hoon |
collection | PubMed |
description | A large body of molecular and neurophysiological evidence connects synaptic plasticity to specific functions and energy metabolism in particular areas of the brain. Furthermore, altered plasticity and energy regulation has been associated with a number of neuropsychiatric disorders. A favourable approach enabling the modulation of neuronal excitability and energy in humans is to stimulate the brain using transcranial direct current stimulation (tDCS) and then to observe the effect on neurometabolites using magnetic resonance spectroscopy (MRS). In this way, a well‐defined modulation of brain energy and excitability can be achieved using a dedicated tDCS protocol to a predetermined brain region. This systematic review was guided by the preferred reporting items for systematic reviews and meta‐analysis and summarises recent literature studying the effect of tDCS on neurometabolites in the human brain as measured by proton or phosphorus MRS. Limitations and recommendations are discussed for future research. The findings of this review provide clear evidence for the potential of using tDCS and MRS to examine and understand the effect of neurometabolites in the in vivo human brain. |
format | Online Article Text |
id | pubmed-8090777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80907772021-05-10 Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review Choi, Chang‐Hoon Iordanishvili, Elene Shah, N. Jon Binkofski, Ferdinand Hum Brain Mapp Review Article A large body of molecular and neurophysiological evidence connects synaptic plasticity to specific functions and energy metabolism in particular areas of the brain. Furthermore, altered plasticity and energy regulation has been associated with a number of neuropsychiatric disorders. A favourable approach enabling the modulation of neuronal excitability and energy in humans is to stimulate the brain using transcranial direct current stimulation (tDCS) and then to observe the effect on neurometabolites using magnetic resonance spectroscopy (MRS). In this way, a well‐defined modulation of brain energy and excitability can be achieved using a dedicated tDCS protocol to a predetermined brain region. This systematic review was guided by the preferred reporting items for systematic reviews and meta‐analysis and summarises recent literature studying the effect of tDCS on neurometabolites in the human brain as measured by proton or phosphorus MRS. Limitations and recommendations are discussed for future research. The findings of this review provide clear evidence for the potential of using tDCS and MRS to examine and understand the effect of neurometabolites in the in vivo human brain. John Wiley & Sons, Inc. 2021-02-26 /pmc/articles/PMC8090777/ /pubmed/33634527 http://dx.doi.org/10.1002/hbm.25388 Text en © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Review Article Choi, Chang‐Hoon Iordanishvili, Elene Shah, N. Jon Binkofski, Ferdinand Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review |
title | Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review |
title_full | Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review |
title_fullStr | Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review |
title_full_unstemmed | Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review |
title_short | Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review |
title_sort | magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8090777/ https://www.ncbi.nlm.nih.gov/pubmed/33634527 http://dx.doi.org/10.1002/hbm.25388 |
work_keys_str_mv | AT choichanghoon magneticresonancespectroscopywithtranscranialdirectcurrentstimulationtoexploretheunderlyingbiochemicalandphysiologicalmechanismofthehumanbrainasystematicreview AT iordanishvilielene magneticresonancespectroscopywithtranscranialdirectcurrentstimulationtoexploretheunderlyingbiochemicalandphysiologicalmechanismofthehumanbrainasystematicreview AT shahnjon magneticresonancespectroscopywithtranscranialdirectcurrentstimulationtoexploretheunderlyingbiochemicalandphysiologicalmechanismofthehumanbrainasystematicreview AT binkofskiferdinand magneticresonancespectroscopywithtranscranialdirectcurrentstimulationtoexploretheunderlyingbiochemicalandphysiologicalmechanismofthehumanbrainasystematicreview |