Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions

Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain poorly understood. We analyze several thousand plasma proteins longitudinally in 306 COVID-19 patients and 78 symptomatic controls, uncovering immune and non-immune proteins linked to COVID-19. Deconvolution of our plasm...

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Autores principales: Filbin, Michael R., Mehta, Arnav, Schneider, Alexis M., Kays, Kyle R., Guess, Jamey R., Gentili, Matteo, Fenyves, Bánk G., Charland, Nicole C., Gonye, Anna L.K., Gushterova, Irena, Khanna, Hargun K., LaSalle, Thomas J., Lavin-Parsons, Kendall M., Lilley, Brendan M., Lodenstein, Carl L., Manakongtreecheep, Kasidet, Margolin, Justin D., McKaig, Brenna N., Rojas-Lopez, Maricarmen, Russo, Brian C., Sharma, Nihaarika, Tantivit, Jessica, Thomas, Molly F., Gerszten, Robert E., Heimberg, Graham S., Hoover, Paul J., Lieb, David J., Lin, Brian, Ngo, Debby, Pelka, Karin, Reyes, Miguel, Smillie, Christopher S., Waghray, Avinash, Wood, Thomas E., Zajac, Amanda S., Jennings, Lori L., Grundberg, Ida, Bhattacharyya, Roby P., Parry, Blair Alden, Villani, Alexandra-Chloé, Sade-Feldman, Moshe, Hacohen, Nir, Goldberg, Marcia B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091031/
https://www.ncbi.nlm.nih.gov/pubmed/33969320
http://dx.doi.org/10.1016/j.xcrm.2021.100287

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