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Is job strain associated with a higher risk of type 2 diabetes mellitus? A systematic review and meta-analysis of prospective cohort studies

OBJECTIVES: Epidemiological studies have explored the relationship between work-related stress and the risk of type 2 diabetes mellitus (T2DM), but it remains unclear on whether work-related stress could increase the risk of T2DM. We aimed to evaluate the association between job strain and the risk...

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Autores principales: Li, Wenzhen, Yi, Guilin, Chen, Zhenlong, Dai, Xiayun, Wu, Jie, Peng, Ying, Ruan, Wenyu, Lu, Zuxun, Wang, Dongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nordic Association of Occupational Safety and Health 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091067/
https://www.ncbi.nlm.nih.gov/pubmed/33404062
http://dx.doi.org/10.5271/sjweh.3938
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author Li, Wenzhen
Yi, Guilin
Chen, Zhenlong
Dai, Xiayun
Wu, Jie
Peng, Ying
Ruan, Wenyu
Lu, Zuxun
Wang, Dongming
author_facet Li, Wenzhen
Yi, Guilin
Chen, Zhenlong
Dai, Xiayun
Wu, Jie
Peng, Ying
Ruan, Wenyu
Lu, Zuxun
Wang, Dongming
author_sort Li, Wenzhen
collection PubMed
description OBJECTIVES: Epidemiological studies have explored the relationship between work-related stress and the risk of type 2 diabetes mellitus (T2DM), but it remains unclear on whether work-related stress could increase the risk of T2DM. We aimed to evaluate the association between job strain and the risk of T2DM. METHODS: We searched PubMed and Web of Science up to April 2019. Summary risk estimates were calculated by random-effect models. And the analysis was also conducted stratifying by gender, study location, smoking, drinking, body mass index, physical activity, family history of T2DM, education and T2DM ascertainment. Studies with binary job strain and quadrants based on the job strain model were analyzed separately. RESULTS: A total of nine studies with 210 939 participants free of T2DM were included in this analysis. High job strain (high job demands and low control) was associated with the overall risk of T2DM compared with no job strain (all other combinations) [relative risk (RR) 1.16, 95% confidence interval (CI) 1.03–1.31], and the association was more evident in women (RR 1.48, 95% CI 1.02–2.14). A statistically significant association was also observed when using high strain as a category (job strain quadrants) rather than binary variable (RR 1.62, 95% CI 1.04–2.55) in women but not men. CONCLUSIONS: Our study suggests that job strain is an important risk factor for T2DM, especially among women. Appropriate preventive interventions in populations with high job strain would contribute to a reduction in T2DM risk.
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spelling pubmed-80910672021-05-04 Is job strain associated with a higher risk of type 2 diabetes mellitus? A systematic review and meta-analysis of prospective cohort studies Li, Wenzhen Yi, Guilin Chen, Zhenlong Dai, Xiayun Wu, Jie Peng, Ying Ruan, Wenyu Lu, Zuxun Wang, Dongming Scand J Work Environ Health Review OBJECTIVES: Epidemiological studies have explored the relationship between work-related stress and the risk of type 2 diabetes mellitus (T2DM), but it remains unclear on whether work-related stress could increase the risk of T2DM. We aimed to evaluate the association between job strain and the risk of T2DM. METHODS: We searched PubMed and Web of Science up to April 2019. Summary risk estimates were calculated by random-effect models. And the analysis was also conducted stratifying by gender, study location, smoking, drinking, body mass index, physical activity, family history of T2DM, education and T2DM ascertainment. Studies with binary job strain and quadrants based on the job strain model were analyzed separately. RESULTS: A total of nine studies with 210 939 participants free of T2DM were included in this analysis. High job strain (high job demands and low control) was associated with the overall risk of T2DM compared with no job strain (all other combinations) [relative risk (RR) 1.16, 95% confidence interval (CI) 1.03–1.31], and the association was more evident in women (RR 1.48, 95% CI 1.02–2.14). A statistically significant association was also observed when using high strain as a category (job strain quadrants) rather than binary variable (RR 1.62, 95% CI 1.04–2.55) in women but not men. CONCLUSIONS: Our study suggests that job strain is an important risk factor for T2DM, especially among women. Appropriate preventive interventions in populations with high job strain would contribute to a reduction in T2DM risk. Nordic Association of Occupational Safety and Health 2021-05-01 2021-04-27 /pmc/articles/PMC8091067/ /pubmed/33404062 http://dx.doi.org/10.5271/sjweh.3938 Text en Copyright: © Scandinavian Journal of Work, Environment & Health https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License.
spellingShingle Review
Li, Wenzhen
Yi, Guilin
Chen, Zhenlong
Dai, Xiayun
Wu, Jie
Peng, Ying
Ruan, Wenyu
Lu, Zuxun
Wang, Dongming
Is job strain associated with a higher risk of type 2 diabetes mellitus? A systematic review and meta-analysis of prospective cohort studies
title Is job strain associated with a higher risk of type 2 diabetes mellitus? A systematic review and meta-analysis of prospective cohort studies
title_full Is job strain associated with a higher risk of type 2 diabetes mellitus? A systematic review and meta-analysis of prospective cohort studies
title_fullStr Is job strain associated with a higher risk of type 2 diabetes mellitus? A systematic review and meta-analysis of prospective cohort studies
title_full_unstemmed Is job strain associated with a higher risk of type 2 diabetes mellitus? A systematic review and meta-analysis of prospective cohort studies
title_short Is job strain associated with a higher risk of type 2 diabetes mellitus? A systematic review and meta-analysis of prospective cohort studies
title_sort is job strain associated with a higher risk of type 2 diabetes mellitus? a systematic review and meta-analysis of prospective cohort studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091067/
https://www.ncbi.nlm.nih.gov/pubmed/33404062
http://dx.doi.org/10.5271/sjweh.3938
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