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Rac1-PAK1 regulation of Rab11 cycling promotes junction destabilization

Rac1 GTPase is hyperactivated in tumors and contributes to malignancy. Rac1 disruption of junctions requires its effector PAK1, but the precise mechanisms are unknown. Here, we show that E-cadherin is internalized via micropinocytosis in a PAK1–dependent manner without catenin dissociation and degra...

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Detalles Bibliográficos
Autores principales:	Erasmus, Jennifer C., Smolarczyk, Kasia, Brezovjakova, Helena, Mohd-Naim, Noor F., Lozano, Encarnación, Matter, Karl, Braga, Vania M.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091128/ https://www.ncbi.nlm.nih.gov/pubmed/33914026 http://dx.doi.org/10.1083/jcb.202002114

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