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Altered selection on a single self-ligand promotes susceptibility to organ-specific T cell infiltration

For the large array of self-peptide/MHC class II (pMHC-II) complexes displayed in the body, it is unclear whether CD4(+) T cell tolerance must be imparted for each individual complex or whether pMHC-II–nonspecific bystander mechanisms are sufficient to confer tolerance by acting broadly on T cells r...

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Detalles Bibliográficos
Autores principales:	Klawon, David E.J., Gilmore, Dana C., Leonard, John D., Miller, Christine H., Chao, Jaime L., Walker, Matthew T., Duncombe, Ryan K., Tung, Kenneth S., Adams, Erin J., Savage, Peter A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091134/ https://www.ncbi.nlm.nih.gov/pubmed/33914024 http://dx.doi.org/10.1084/jem.20200701

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