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Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy

Multiple system atrophy (MSA) is an insidious middle age-onset neurodegenerative disease that clinically presents with variable degrees of parkinsonism and cerebellar ataxia. The pathological hallmark of MSA is the progressive accumulation of glial cytoplasmic inclusions (GCIs) in oligodendrocytes t...

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Detalles Bibliográficos
Autores principales: Hass, Ethan W., Sorrentino, Zachary A., Lloyd, Grace M., McFarland, Nikolaus R., Prokop, Stefan, Giasson, Benoit I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091528/
https://www.ncbi.nlm.nih.gov/pubmed/33941284
http://dx.doi.org/10.1186/s40478-021-01173-y