NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation

Tumor necrosis factor receptor 1 (TNFR1) activates NF-κB–dependent pro-inflammatory gene expression, but also induces cell death by triggering apoptosis and necroptosis. Inhibition of inhibitor of NF-κB kinase (IKK)/NF-κB signaling in keratinocytes paradoxically unleashed spontaneous TNFR1-mediated...

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Detalles Bibliográficos
Autores principales: Kumari, Snehlata, Van, Trieu-My, Preukschat, Daniela, Schuenke, Hannah, Basic, Marijana, Bleich, André, Klein, Ulf, Pasparakis, Manolis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091601/
https://www.ncbi.nlm.nih.gov/pubmed/33858959
http://dx.doi.org/10.26508/lsa.202000956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091601/
https://www.ncbi.nlm.nih.gov/pubmed/33858959
http://dx.doi.org/10.26508/lsa.202000956

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