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COXIBs and 2,5-dimethylcelecoxib counteract the hyperactivated Wnt/β-catenin pathway and COX-2/PGE2/EP4 signaling in glioblastoma cells

BACKGROUND: Glioblastoma (GBM) is the deadliest and the most common primary brain tumor in adults. The invasiveness and proliferation of GBM cells can be decreased through the inhibition of Wnt/β-catenin pathway. In this regard, celecoxib is a promising agent, but other COXIBs and 2,5-dimethylceleco...

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Detalles Bibliográficos
Autores principales:	Majchrzak-Celińska, Aleksandra, Misiorek, Julia O., Kruhlenia, Nastassia, Przybyl, Lukasz, Kleszcz, Robert, Rolle, Katarzyna, Krajka-Kuźniak, Violetta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091781/ https://www.ncbi.nlm.nih.gov/pubmed/33941107 http://dx.doi.org/10.1186/s12885-021-08164-1

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