Cargando…
Establishing and maintaining fertility: the importance of cell cycle arrest
Development of the ovary or testis is required to establish reproductive competence. Gonad development relies on key cell fate decisions that occur early in embryonic development and are actively maintained. During gonad development, both germ cells and somatic cells proliferate extensively, a proce...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091977/ https://www.ncbi.nlm.nih.gov/pubmed/33888561 http://dx.doi.org/10.1101/gad.348151.120 |
_version_ | 1783687575036231680 |
---|---|
author | Frost, Emily R. Taylor, Güneş Baker, Mark A. Lovell-Badge, Robin Sutherland, Jessie M. |
author_facet | Frost, Emily R. Taylor, Güneş Baker, Mark A. Lovell-Badge, Robin Sutherland, Jessie M. |
author_sort | Frost, Emily R. |
collection | PubMed |
description | Development of the ovary or testis is required to establish reproductive competence. Gonad development relies on key cell fate decisions that occur early in embryonic development and are actively maintained. During gonad development, both germ cells and somatic cells proliferate extensively, a process facilitated by cell cycle regulation. This review focuses on the Cip/Kip family of cyclin-dependent kinase inhibitors (CKIs) in mouse gonad development. We particularly highlight recent single-cell RNA sequencing studies that show the heterogeneity of cyclin-dependent kinase inhibitors. This diversity highlights new roles for cell cycle inhibitors in controlling and maintaining female fertility. |
format | Online Article Text |
id | pubmed-8091977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-80919772021-05-14 Establishing and maintaining fertility: the importance of cell cycle arrest Frost, Emily R. Taylor, Güneş Baker, Mark A. Lovell-Badge, Robin Sutherland, Jessie M. Genes Dev Review Development of the ovary or testis is required to establish reproductive competence. Gonad development relies on key cell fate decisions that occur early in embryonic development and are actively maintained. During gonad development, both germ cells and somatic cells proliferate extensively, a process facilitated by cell cycle regulation. This review focuses on the Cip/Kip family of cyclin-dependent kinase inhibitors (CKIs) in mouse gonad development. We particularly highlight recent single-cell RNA sequencing studies that show the heterogeneity of cyclin-dependent kinase inhibitors. This diversity highlights new roles for cell cycle inhibitors in controlling and maintaining female fertility. Cold Spring Harbor Laboratory Press 2021-05-01 /pmc/articles/PMC8091977/ /pubmed/33888561 http://dx.doi.org/10.1101/gad.348151.120 Text en © 2021 Frost et al.; Published by Cold Spring Harbor Laboratory Press https://creativecommons.org/licenses/by/4.0/This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Frost, Emily R. Taylor, Güneş Baker, Mark A. Lovell-Badge, Robin Sutherland, Jessie M. Establishing and maintaining fertility: the importance of cell cycle arrest |
title | Establishing and maintaining fertility: the importance of cell cycle arrest |
title_full | Establishing and maintaining fertility: the importance of cell cycle arrest |
title_fullStr | Establishing and maintaining fertility: the importance of cell cycle arrest |
title_full_unstemmed | Establishing and maintaining fertility: the importance of cell cycle arrest |
title_short | Establishing and maintaining fertility: the importance of cell cycle arrest |
title_sort | establishing and maintaining fertility: the importance of cell cycle arrest |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091977/ https://www.ncbi.nlm.nih.gov/pubmed/33888561 http://dx.doi.org/10.1101/gad.348151.120 |
work_keys_str_mv | AT frostemilyr establishingandmaintainingfertilitytheimportanceofcellcyclearrest AT taylorgunes establishingandmaintainingfertilitytheimportanceofcellcyclearrest AT bakermarka establishingandmaintainingfertilitytheimportanceofcellcyclearrest AT lovellbadgerobin establishingandmaintainingfertilitytheimportanceofcellcyclearrest AT sutherlandjessiem establishingandmaintainingfertilitytheimportanceofcellcyclearrest |