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Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations

Our current understanding of how low antibiotic concentrations shape the evolution of contemporary β-lactamases is limited. Using the widespread carbapenemase OXA-48, we tested the long-standing hypothesis that selective compartments with low antibiotic concentrations cause standing genetic diversit...

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Detalles Bibliográficos
Autores principales:	Fröhlich, Christopher, Gama, João A., Harms, Klaus, Hirvonen, Viivi H. A., Lund, Bjarte A., van der Kamp, Marc W., Johnsen, Pål J., Samuelsen, Ørjan, Leiros, Hanna-Kirsti S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092134/ https://www.ncbi.nlm.nih.gov/pubmed/33910990 http://dx.doi.org/10.1128/mSphere.00108-21

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