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Pregnancy outcomes following exposure to efavirenz based antiretroviral therapy in indian women
OBJECTIVES: Mother-to-child transmission of HIV has witnessed a significant reduction due to effective antiretroviral therapy (ART). Efavirenz has been introduced as a part of ART since last few years in the national Prevention of Parent to Child Transmission (PPTCT) program for pregnant women livin...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092176/ https://www.ncbi.nlm.nih.gov/pubmed/33666186 http://dx.doi.org/10.4103/ijp.IJP_263_20 |
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author | Mishra, Rajesh Kumar Chakravarty, Rony Siddique, Nilopher Pandey, Kirit Rajendra |
author_facet | Mishra, Rajesh Kumar Chakravarty, Rony Siddique, Nilopher Pandey, Kirit Rajendra |
author_sort | Mishra, Rajesh Kumar |
collection | PubMed |
description | OBJECTIVES: Mother-to-child transmission of HIV has witnessed a significant reduction due to effective antiretroviral therapy (ART). Efavirenz has been introduced as a part of ART since last few years in the national Prevention of Parent to Child Transmission (PPTCT) program for pregnant women living with HIV. However, data related to adverse pregnancy outcomes associated with efavirenz-based ART are limited in the Indian scenario. The present study evaluated pregnancy outcomes in HIV-infected pregnant women who were given efavirenz-based ART during pregnancy. MATERIALS AND METHODS: It is a retrospective, observational, analytic study carried out at a referral hospital in Western India. Collection of data was done for a period of 5 years, and various adverse outcomes were studied which included preterm delivery, low birth weight (LBW), stillbirths, congenital anomaly, and neonatal death. RESULTS: This study showed a preterm birth rate of 19% and LBW in 36% of cases. There was no significant association with congenital anomaly, stillbirth, or neonatal death. CONCLUSION: There was an association of exposure to efavirenz with an increased incidence of adverse pregnancy outcomes, especially LBW infants. This study emphasizes the requirement of large prospective studies to investigate fetomaternal outcomes in pregnant women exposed to efavirenz. |
format | Online Article Text |
id | pubmed-8092176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-80921762021-05-06 Pregnancy outcomes following exposure to efavirenz based antiretroviral therapy in indian women Mishra, Rajesh Kumar Chakravarty, Rony Siddique, Nilopher Pandey, Kirit Rajendra Indian J Pharmacol Research Article OBJECTIVES: Mother-to-child transmission of HIV has witnessed a significant reduction due to effective antiretroviral therapy (ART). Efavirenz has been introduced as a part of ART since last few years in the national Prevention of Parent to Child Transmission (PPTCT) program for pregnant women living with HIV. However, data related to adverse pregnancy outcomes associated with efavirenz-based ART are limited in the Indian scenario. The present study evaluated pregnancy outcomes in HIV-infected pregnant women who were given efavirenz-based ART during pregnancy. MATERIALS AND METHODS: It is a retrospective, observational, analytic study carried out at a referral hospital in Western India. Collection of data was done for a period of 5 years, and various adverse outcomes were studied which included preterm delivery, low birth weight (LBW), stillbirths, congenital anomaly, and neonatal death. RESULTS: This study showed a preterm birth rate of 19% and LBW in 36% of cases. There was no significant association with congenital anomaly, stillbirth, or neonatal death. CONCLUSION: There was an association of exposure to efavirenz with an increased incidence of adverse pregnancy outcomes, especially LBW infants. This study emphasizes the requirement of large prospective studies to investigate fetomaternal outcomes in pregnant women exposed to efavirenz. Wolters Kluwer - Medknow 2020 2021-02-19 /pmc/articles/PMC8092176/ /pubmed/33666186 http://dx.doi.org/10.4103/ijp.IJP_263_20 Text en Copyright: © 2021 Indian Journal of Pharmacology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Research Article Mishra, Rajesh Kumar Chakravarty, Rony Siddique, Nilopher Pandey, Kirit Rajendra Pregnancy outcomes following exposure to efavirenz based antiretroviral therapy in indian women |
title | Pregnancy outcomes following exposure to efavirenz based antiretroviral therapy in indian women |
title_full | Pregnancy outcomes following exposure to efavirenz based antiretroviral therapy in indian women |
title_fullStr | Pregnancy outcomes following exposure to efavirenz based antiretroviral therapy in indian women |
title_full_unstemmed | Pregnancy outcomes following exposure to efavirenz based antiretroviral therapy in indian women |
title_short | Pregnancy outcomes following exposure to efavirenz based antiretroviral therapy in indian women |
title_sort | pregnancy outcomes following exposure to efavirenz based antiretroviral therapy in indian women |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092176/ https://www.ncbi.nlm.nih.gov/pubmed/33666186 http://dx.doi.org/10.4103/ijp.IJP_263_20 |
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