Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State

The human immunodeficiency virus type 1 (HIV-1) envelope trimer maintains a closed, metastable configuration to protect vulnerable epitopes from neutralizing antibodies. Here, we identify key hydrophobic constraints at the trimer apex that function as global stabilizers of the HIV-1 envelope spike c...

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Detalles Bibliográficos
Autores principales: Zhang, Peng, Kwon, Alice L., Guzzo, Christina, Liu, Qingbo, Schmeisser, Hana, Miao, Huiyi, Lin, Yin, Cimbro, Raffaello, Huang, Jinghe, Connors, Mark, Schmidt, Stephen D., Dolan, Michael A., Armstrong, Anthony A., Lusso, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092198/
https://www.ncbi.nlm.nih.gov/pubmed/33785631
http://dx.doi.org/10.1128/mBio.00090-21

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