Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection

Monoclonal antibody (MAb) 2C7 recognizes a lipooligosaccharide epitope expressed by most clinical Neisseria gonorrhoeae isolates and mediates complement-dependent bactericidal activity. We recently showed that a recombinant human IgG1 chimeric variant of MAb 2C7 containing an E430G Fc modification (...

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Detalles Bibliográficos
Autores principales: Parzych, Elizabeth M., Gulati, Sunita, Zheng, Bo, Bah, Mamadou A., Elliott, Sarah T. C., Chu, Jacqueline D., Nowak, Nancy, Reed, George W., Beurskens, Frank J., Schuurman, Janine, Rice, Peter A., Weiner, David B., Ram, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092225/
https://www.ncbi.nlm.nih.gov/pubmed/33727348
http://dx.doi.org/10.1128/mBio.00242-21

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