Improving the Precision of Base Editing by Bubble Hairpin Single Guide RNA

Base editing is a powerful genome editing approach that enables single-nucleotide changes without double-stranded DNA breaks (DSBs). However, off-target effects as well as other undesired editings at on-target sites remain obstacles for its application. Here, we report that bubble hairpin single gui...

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Detalles Bibliográficos
Autores principales: Hu, Zhiwei, Wang, Yannan, Liu, Qian, Qiu, Yan, Zhong, Zhiyu, Li, Kangdi, Li, Wenhua, Deng, Zixin, Sun, Yuhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092237/
https://www.ncbi.nlm.nih.gov/pubmed/33879582
http://dx.doi.org/10.1128/mBio.00342-21

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