Human Cytomegalovirus miR-US25-1 Targets the GTPase RhoA To Inhibit CD34(+) Hematopoietic Progenitor Cell Proliferation To Maintain the Latent Viral Genome

Human cytomegalovirus (HCMV) microRNAs play essential roles in latency and reactivation in CD34(+) hematopoietic progenitor cells (HPCs) via regulation of viral and cellular gene expression. In the present study, we show that HCMV miR-US25-1 targets RhoA, a small GTPase required for CD34(+) HPC self...

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Detalles Bibliográficos
Autores principales: Diggins, Nicole L., Crawford, Lindsey B., Hancock, Meaghan H., Mitchell, Jennifer, Nelson, Jay A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092260/
https://www.ncbi.nlm.nih.gov/pubmed/33824207
http://dx.doi.org/10.1128/mBio.00621-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092260/
https://www.ncbi.nlm.nih.gov/pubmed/33824207
http://dx.doi.org/10.1128/mBio.00621-21

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