Introduction of Two Prolines and Removal of the Polybasic Cleavage Site Lead to Higher Efficacy of a Recombinant Spike-Based SARS-CoV-2 Vaccine in the Mouse Model

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the prime target for vaccine development. The spike protein mediates both binding to host cells and membrane fusion and is also so far the only known viral target of neutralizing antibodies. Coro...

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Detalles Bibliográficos
Autores principales: Amanat, Fatima, Strohmeier, Shirin, Rathnasinghe, Raveen, Schotsaert, Michael, Coughlan, Lynda, García-Sastre, Adolfo, Krammer, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092267/
https://www.ncbi.nlm.nih.gov/pubmed/33653892
http://dx.doi.org/10.1128/mBio.02648-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092267/
https://www.ncbi.nlm.nih.gov/pubmed/33653892
http://dx.doi.org/10.1128/mBio.02648-20

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