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Mycobacterium tuberculosis Toxin CpnT Is an ESX-5 Substrate and Requires Three Type VII Secretion Systems for Intracellular Secretion

CpnT, a NAD(+) glycohydrolase, is the only known toxin that is secreted by Mycobacterium tuberculosis. CpnT is composed of two domains; the C-terminal domain is the toxin, whereas the N-terminal domain is required for secretion. CpnT shows characteristics of type VII secretion (T7S) substrates, incl...

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Detalles Bibliográficos
Autores principales:	Izquierdo Lafuente, B., Ummels, R., Kuijl, C., Bitter, W., Speer, A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092274/ https://www.ncbi.nlm.nih.gov/pubmed/33653883 http://dx.doi.org/10.1128/mBio.02983-20

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