The Lst Sialyltransferase of Neisseria gonorrhoeae Can Transfer Keto-Deoxyoctanoate as the Terminal Sugar of Lipooligosaccharide: a Glyco-Achilles Heel That Provides a New Strategy for Vaccines to Prevent Gonorrhea

The lipooligosaccharide (LOS) of Neisseria gonorrhoeae plays key roles in pathogenesis and is composed of multiple possible glycoforms. These glycoforms are generated by the process of phase variation and by differences in the glycosyltransferase gene content of particular strains. LOS glycoforms of...

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Detalles Bibliográficos
Autores principales: Jen, Freda E.-C., Ketterer, Margaret R., Semchenko, Evgeny A., Day, Christopher J., Seib, Kate L., Apicella, Michael A., Jennings, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092323/
https://www.ncbi.nlm.nih.gov/pubmed/33758087
http://dx.doi.org/10.1128/mBio.03666-20

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