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Teriparatide and Abaloparatide Have a Similar Effect on Bone in Mice

Three bone anabolic pharmaceuticals are currently approved for treatment of osteoporosis, teriparatide (PTH (1–34)), the parathyroid hormone-related protein analog abaloparatide (ABL), and romosozumab. The present study compared the effect of intermittent PTH (1–34) and ABL on bone tissue directly m...

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Autores principales: Brent, Mikkel Bo, Stoltenborg, Frederik Eriksen, Brüel, Annemarie, Thomsen, Jesper Skovhus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092394/
https://www.ncbi.nlm.nih.gov/pubmed/33953694
http://dx.doi.org/10.3389/fendo.2021.628994
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author Brent, Mikkel Bo
Stoltenborg, Frederik Eriksen
Brüel, Annemarie
Thomsen, Jesper Skovhus
author_facet Brent, Mikkel Bo
Stoltenborg, Frederik Eriksen
Brüel, Annemarie
Thomsen, Jesper Skovhus
author_sort Brent, Mikkel Bo
collection PubMed
description Three bone anabolic pharmaceuticals are currently approved for treatment of osteoporosis, teriparatide (PTH (1–34)), the parathyroid hormone-related protein analog abaloparatide (ABL), and romosozumab. The present study compared the effect of intermittent PTH (1–34) and ABL on bone tissue directly mole-to-mole in female mice. Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12). The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks. To assess the effect of PTH and ABL, the hindlimb bones were analyzed with DXA, µCT, mechanical testing, dynamic bone histomorphometry, and histological quantification of bone cells. In addition, serum calcium concentration was determined. PTH and ABL significantly increased femoral areal bone mineral density (aBMD) (borderline significant p = 0.06 for PTH), femoral mid-diaphyseal bone strength, femoral metaphyseal and epiphyseal and vertebral bone volume fraction (BV/TV), connectivity density, volumetric bone mineral density (vBMD), and bone formation rate (BFR/BS) compared to Ctrl. In addition, ABL also significantly increased mid-diaphyseal cortical thickness and bone area compared to Ctrl. Neither PTH nor ABL significantly increased bone strength at the femoral neck. In conclusion, abaloparatide and PTH have similar bone anabolic properties when compared directly mole-to-mole in mice.
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spelling pubmed-80923942021-05-04 Teriparatide and Abaloparatide Have a Similar Effect on Bone in Mice Brent, Mikkel Bo Stoltenborg, Frederik Eriksen Brüel, Annemarie Thomsen, Jesper Skovhus Front Endocrinol (Lausanne) Endocrinology Three bone anabolic pharmaceuticals are currently approved for treatment of osteoporosis, teriparatide (PTH (1–34)), the parathyroid hormone-related protein analog abaloparatide (ABL), and romosozumab. The present study compared the effect of intermittent PTH (1–34) and ABL on bone tissue directly mole-to-mole in female mice. Forty-seven C57BL/6 mice were randomly allocated to the following groups: Baseline (n = 11), Control (Ctrl) (n = 12), PTH (n = 12), and ABL (n = 12). The mice were injected s.c. with PTH (100 µg/kg), ABL (96 µg/kg), or saline (Ctrl) five days a week for three weeks. To assess the effect of PTH and ABL, the hindlimb bones were analyzed with DXA, µCT, mechanical testing, dynamic bone histomorphometry, and histological quantification of bone cells. In addition, serum calcium concentration was determined. PTH and ABL significantly increased femoral areal bone mineral density (aBMD) (borderline significant p = 0.06 for PTH), femoral mid-diaphyseal bone strength, femoral metaphyseal and epiphyseal and vertebral bone volume fraction (BV/TV), connectivity density, volumetric bone mineral density (vBMD), and bone formation rate (BFR/BS) compared to Ctrl. In addition, ABL also significantly increased mid-diaphyseal cortical thickness and bone area compared to Ctrl. Neither PTH nor ABL significantly increased bone strength at the femoral neck. In conclusion, abaloparatide and PTH have similar bone anabolic properties when compared directly mole-to-mole in mice. Frontiers Media S.A. 2021-04-19 /pmc/articles/PMC8092394/ /pubmed/33953694 http://dx.doi.org/10.3389/fendo.2021.628994 Text en Copyright © 2021 Brent, Stoltenborg, Brüel and Thomsen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Brent, Mikkel Bo
Stoltenborg, Frederik Eriksen
Brüel, Annemarie
Thomsen, Jesper Skovhus
Teriparatide and Abaloparatide Have a Similar Effect on Bone in Mice
title Teriparatide and Abaloparatide Have a Similar Effect on Bone in Mice
title_full Teriparatide and Abaloparatide Have a Similar Effect on Bone in Mice
title_fullStr Teriparatide and Abaloparatide Have a Similar Effect on Bone in Mice
title_full_unstemmed Teriparatide and Abaloparatide Have a Similar Effect on Bone in Mice
title_short Teriparatide and Abaloparatide Have a Similar Effect on Bone in Mice
title_sort teriparatide and abaloparatide have a similar effect on bone in mice
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092394/
https://www.ncbi.nlm.nih.gov/pubmed/33953694
http://dx.doi.org/10.3389/fendo.2021.628994
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