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Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health
BACKGROUND: The metabolic syndrome (MetS) is correlated with disorders of the reproductive system, such as the polycystic ovary syndrome (PCOS). While consumption of a diet rich in carbohydrates is linked to the development of MetS, it is still unclear if this diet leads to ovarian dysfunction and P...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092397/ https://www.ncbi.nlm.nih.gov/pubmed/33953699 http://dx.doi.org/10.3389/fendo.2021.656831 |
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author | de Melo, Giuliane Barros Soares, Jéssica Furtado Costa, Thamyres Cristhina Lima Benevides, Renata Ohana Alves Vale, Caroline Castro Paes, Antonio Marcus de Andrade Gaspar, Renato Simões |
author_facet | de Melo, Giuliane Barros Soares, Jéssica Furtado Costa, Thamyres Cristhina Lima Benevides, Renata Ohana Alves Vale, Caroline Castro Paes, Antonio Marcus de Andrade Gaspar, Renato Simões |
author_sort | de Melo, Giuliane Barros |
collection | PubMed |
description | BACKGROUND: The metabolic syndrome (MetS) is correlated with disorders of the reproductive system, such as the polycystic ovary syndrome (PCOS). While consumption of a diet rich in carbohydrates is linked to the development of MetS, it is still unclear if this diet leads to ovarian dysfunction and PCOS. OBJECTIVES: We investigated the influence of a high-sucrose diet (HSD) on the ovarian milieu of Wistar rats and studied the correlation between high consumption of sugary drinks and the prevalence of PCOS in women. METHODS: Wistar rats were given a standard laboratory diet (CTR, 10% sucrose, n = 8) or HSD (HSD, 25% sucrose, n = 8) from postnatal day 21 to 120. Animals were evaluated weekly to calculate food intake, feed efficiency and weight gain. Both onset of puberty and estrous cycle were monitored. Metabolic serum biochemistry, organ morphometry and ovarian histology were performed upon euthanasia. In parallel, a fixed-effects multiple linear regression analysis was performed using data from Brazilian states (459 state-year observations) to test the correlation between the consumption of sugar-sweetened beverages (surrogate for HSD intake) and the prevalence of PCOS (surrogate for ovarian dysfunction). RESULTS: HSD animals showed increased adipose tissue accumulation, hyperglycaemia and insulin resistance when compared to CTR. Interestingly HSD rats also entered puberty earlier than CTR. Moreover, ovaries from HSD animals had an increased number of atretic antral follicles and cystic follicles, which were correlated with the hypertrophy of periovarian adipocytes. Finally, there was a positive correlation between the intake of sugary drinks and prevalence of PCOS in women of reproductive age. CONCLUSIONS: HSD ingestion leads to ovarian dysfunction in rats and could be correlated with PCOS in women, suggesting these alterations could lead to public health issues. Therefore, we reinforce the deleterious impact of HSD to the ovarian system and suggest that the reduction of added sugars intake could be beneficial to ovarian health. |
format | Online Article Text |
id | pubmed-8092397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80923972021-05-04 Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health de Melo, Giuliane Barros Soares, Jéssica Furtado Costa, Thamyres Cristhina Lima Benevides, Renata Ohana Alves Vale, Caroline Castro Paes, Antonio Marcus de Andrade Gaspar, Renato Simões Front Endocrinol (Lausanne) Endocrinology BACKGROUND: The metabolic syndrome (MetS) is correlated with disorders of the reproductive system, such as the polycystic ovary syndrome (PCOS). While consumption of a diet rich in carbohydrates is linked to the development of MetS, it is still unclear if this diet leads to ovarian dysfunction and PCOS. OBJECTIVES: We investigated the influence of a high-sucrose diet (HSD) on the ovarian milieu of Wistar rats and studied the correlation between high consumption of sugary drinks and the prevalence of PCOS in women. METHODS: Wistar rats were given a standard laboratory diet (CTR, 10% sucrose, n = 8) or HSD (HSD, 25% sucrose, n = 8) from postnatal day 21 to 120. Animals were evaluated weekly to calculate food intake, feed efficiency and weight gain. Both onset of puberty and estrous cycle were monitored. Metabolic serum biochemistry, organ morphometry and ovarian histology were performed upon euthanasia. In parallel, a fixed-effects multiple linear regression analysis was performed using data from Brazilian states (459 state-year observations) to test the correlation between the consumption of sugar-sweetened beverages (surrogate for HSD intake) and the prevalence of PCOS (surrogate for ovarian dysfunction). RESULTS: HSD animals showed increased adipose tissue accumulation, hyperglycaemia and insulin resistance when compared to CTR. Interestingly HSD rats also entered puberty earlier than CTR. Moreover, ovaries from HSD animals had an increased number of atretic antral follicles and cystic follicles, which were correlated with the hypertrophy of periovarian adipocytes. Finally, there was a positive correlation between the intake of sugary drinks and prevalence of PCOS in women of reproductive age. CONCLUSIONS: HSD ingestion leads to ovarian dysfunction in rats and could be correlated with PCOS in women, suggesting these alterations could lead to public health issues. Therefore, we reinforce the deleterious impact of HSD to the ovarian system and suggest that the reduction of added sugars intake could be beneficial to ovarian health. Frontiers Media S.A. 2021-04-19 /pmc/articles/PMC8092397/ /pubmed/33953699 http://dx.doi.org/10.3389/fendo.2021.656831 Text en Copyright © 2021 de Melo, Soares, Costa, Benevides, Vale, Paes and Gaspar https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology de Melo, Giuliane Barros Soares, Jéssica Furtado Costa, Thamyres Cristhina Lima Benevides, Renata Ohana Alves Vale, Caroline Castro Paes, Antonio Marcus de Andrade Gaspar, Renato Simões Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health |
title | Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health |
title_full | Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health |
title_fullStr | Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health |
title_full_unstemmed | Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health |
title_short | Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health |
title_sort | early exposure to high-sucrose diet leads to deteriorated ovarian health |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092397/ https://www.ncbi.nlm.nih.gov/pubmed/33953699 http://dx.doi.org/10.3389/fendo.2021.656831 |
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