Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs

Cancer cells can survive chemotherapy-induced stress, but how they recover from it is not known. Using a temporal multiomics approach, we delineate the global mechanisms of proteotoxic stress resolution in multiple myeloma cells recovering from proteasome inhibition. Our observations define layered...

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Detalles Bibliográficos
Autores principales: Saavedra-García, Paula, Roman-Trufero, Monica, Al-Sadah, Hibah A., Blighe, Kevin, López-Jiménez, Elena, Christoforou, Marilena, Penfold, Lucy, Capece, Daria, Xiong, Xiaobei, Miao, Yirun, Parzych, Katarzyna, Caputo, Valentina S., Siskos, Alexandros P., Encheva, Vesela, Liu, Zijing, Thiel, Denise, Kaiser, Martin F., Piazza, Paolo, Chaidos, Aristeidis, Karadimitris, Anastasios, Franzoso, Guido, Snijders, Ambrosius P., Keun, Hector C., Oyarzún, Diego A., Barahona, Mauricio, Auner, Holger W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092411/
https://www.ncbi.nlm.nih.gov/pubmed/33883278
http://dx.doi.org/10.1073/pnas.2018229118

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