DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defects

DDX11 encodes an iron–sulfur cluster DNA helicase required for development, mutated, and overexpressed in cancers. Here, we show that loss of DDX11 causes replication stress and sensitizes cancer cells to DNA damaging agents, including poly ADP ribose polymerase (PARP) inhibitors and platinum drugs....

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Detalles Bibliográficos
Autores principales: Jegadesan, Nanda Kumar, Branzei, Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092582/
https://www.ncbi.nlm.nih.gov/pubmed/33879618
http://dx.doi.org/10.1073/pnas.2024258118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092582/
https://www.ncbi.nlm.nih.gov/pubmed/33879618
http://dx.doi.org/10.1073/pnas.2024258118

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