Adeno-associated Virus (AAV) Capsid Chimeras with Enhanced Infectivity Reveal a Core Element in the AAV Genome Critical for both Cell Transduction and Capsid Assembly

Adeno-associated viruses (AAVs) have attracted significant attention in the field of gene and cell therapy due to their use in highly effective delivery of therapeutic genes into human cells. The ability to generate recombinant AAV (rAAV) vectors comprising unique or substituted protein sequences ha...

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Detalles Bibliográficos
Autores principales: Viney, Lydia, Bürckstümmer, Tilmann, Eddington, Courtnee, Mietzsch, Mario, Choudhry, Modassir, Henley, Tom, Agbandje-McKenna, Mavis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Gene Delivery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092683/
https://www.ncbi.nlm.nih.gov/pubmed/33441336
http://dx.doi.org/10.1128/JVI.02023-20

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