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Thousands of protein linear motif classes may still be undiscovered
Linear motifs are short protein subsequences that mediate protein interactions. Hundreds of motif classes including thousands of motif instances are known. Our theory estimates how many motif classes remain undiscovered. As commonly done, we describe motif classes as regular expressions specifying m...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092775/ https://www.ncbi.nlm.nih.gov/pubmed/33939703 http://dx.doi.org/10.1371/journal.pone.0248841 |
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author | Bulavka, Denys Aptekmann, Ariel A. Méndez, Nicolás A. Krick, Teresa Sánchez, Ignacio E. |
author_facet | Bulavka, Denys Aptekmann, Ariel A. Méndez, Nicolás A. Krick, Teresa Sánchez, Ignacio E. |
author_sort | Bulavka, Denys |
collection | PubMed |
description | Linear motifs are short protein subsequences that mediate protein interactions. Hundreds of motif classes including thousands of motif instances are known. Our theory estimates how many motif classes remain undiscovered. As commonly done, we describe motif classes as regular expressions specifying motif length and the allowed amino acids at each motif position. We measure motif specificity for a pair of motif classes by quantifying how many motif-discriminating positions prevent a protein subsequence from matching the two classes at once. We derive theorems for the maximal number of motif classes that can simultaneously maintain a certain number of motif-discriminating positions between all pairs of classes in the motif universe, for a given amino acid alphabet. We also calculate the fraction of all protein subsequences that would belong to a motif class if all potential motif classes came into existence. Naturally occurring pairs of motif classes present most often a single motif-discriminating position. This mild specificity maximizes the potential number of coexisting motif classes, the expansion of the motif universe due to amino acid modifications and the fraction of amino acid sequences that code for a motif instance. As a result, thousands of linear motif classes may remain undiscovered. |
format | Online Article Text |
id | pubmed-8092775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-80927752021-05-07 Thousands of protein linear motif classes may still be undiscovered Bulavka, Denys Aptekmann, Ariel A. Méndez, Nicolás A. Krick, Teresa Sánchez, Ignacio E. PLoS One Research Article Linear motifs are short protein subsequences that mediate protein interactions. Hundreds of motif classes including thousands of motif instances are known. Our theory estimates how many motif classes remain undiscovered. As commonly done, we describe motif classes as regular expressions specifying motif length and the allowed amino acids at each motif position. We measure motif specificity for a pair of motif classes by quantifying how many motif-discriminating positions prevent a protein subsequence from matching the two classes at once. We derive theorems for the maximal number of motif classes that can simultaneously maintain a certain number of motif-discriminating positions between all pairs of classes in the motif universe, for a given amino acid alphabet. We also calculate the fraction of all protein subsequences that would belong to a motif class if all potential motif classes came into existence. Naturally occurring pairs of motif classes present most often a single motif-discriminating position. This mild specificity maximizes the potential number of coexisting motif classes, the expansion of the motif universe due to amino acid modifications and the fraction of amino acid sequences that code for a motif instance. As a result, thousands of linear motif classes may remain undiscovered. Public Library of Science 2021-05-03 /pmc/articles/PMC8092775/ /pubmed/33939703 http://dx.doi.org/10.1371/journal.pone.0248841 Text en © 2021 Bulavka et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Bulavka, Denys Aptekmann, Ariel A. Méndez, Nicolás A. Krick, Teresa Sánchez, Ignacio E. Thousands of protein linear motif classes may still be undiscovered |
title | Thousands of protein linear motif classes may still be undiscovered |
title_full | Thousands of protein linear motif classes may still be undiscovered |
title_fullStr | Thousands of protein linear motif classes may still be undiscovered |
title_full_unstemmed | Thousands of protein linear motif classes may still be undiscovered |
title_short | Thousands of protein linear motif classes may still be undiscovered |
title_sort | thousands of protein linear motif classes may still be undiscovered |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092775/ https://www.ncbi.nlm.nih.gov/pubmed/33939703 http://dx.doi.org/10.1371/journal.pone.0248841 |
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