Cargando…

Potency of Olorofim (F901318) Compared to Contemporary Antifungal Agents against Clinical Aspergillus fumigatus Isolates and Review of Azole Resistance Phenotype and Genotype Epidemiology in China

Triazole resistance in Aspergillus fumigatus is an increasing worldwide problem that causes major challenges in the management of aspergillosis. New antifungal drugs are needed, with novel targets, that are effective in triazole-resistant infection. In this study, we retrospectively evaluated the po...

Descripción completa

Detalles Bibliográficos
Autores principales:	Su, Huilin, Zhu, Min, Tsui, Clement Kin-Ming, van der Lee, Henrich, Tehupeiory-Kooreman, Marlou, Zoll, Jan, Engel, Tobias, Li, Li, Zhu, Junhao, Lu, Zihan, Zhang, Qiangqiang, Verweij, Paul E., Deng, Shuwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Susceptibility
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092882/ https://www.ncbi.nlm.nih.gov/pubmed/33685896 http://dx.doi.org/10.1128/AAC.02546-20

Ejemplares similares

Resistance profiling of Aspergillus fumigatus to olorofim indicates absence of intrinsic resistance and unveils the molecular mechanisms of acquired olorofim resistance
por: Buil, Jochem B., et al.
Publicado: (2022)

In Vitro Activity of Chlorhexidine Compared with Seven Antifungal Agents against 98 Fusarium Isolates Recovered from Fungal Keratitis Patients
por: Oliveira dos Santos, Claudy, et al.
Publicado: (2019)

The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus
por: du Pré, Saskia, et al.
Publicado: (2020)

Evaluation of MIC Strip Isavuconazole Test for Susceptibility Testing of Wild-Type and Non-Wild-Type Aspergillus fumigatus Isolates
por: Arendrup, Maiken Cavling, et al.
Publicado: (2016)

Antagonism of the Azoles to Olorofim and Cross-Resistance Are Governed by Linked Transcriptional Networks in Aspergillus fumigatus
por: van Rhijn, Norman, et al.
Publicado: (2022)

Potency of Omadacycline against Mycobacteroides abscessus Clinical Isolates In Vitro and in a Mouse Model of Pulmonary Infection
por: Nicklas, Danielle A., et al.
Publicado: (2022)

EUCAST Susceptibility Testing of Isavuconazole: MIC Data for Contemporary Clinical Mold and Yeast Isolates
por: Jørgensen, Karin Meinike, et al.
Publicado: (2019)

In Vitro Activity of Delafloxacin against Contemporary Bacterial Pathogens from the United States and Europe, 2014
por: Pfaller, M. A., et al.
Publicado: (2017)

Azole-Resistant Aspergillus fumigatus, Iran
por: Seyedmousavi, Seyedmojtaba, et al.
Publicado: (2013)

Activity of a Long-Acting Echinocandin, Rezafungin, and Comparator Antifungal Agents Tested against Contemporary Invasive Fungal Isolates (SENTRY Program, 2016 to 2018)
por: Pfaller, Michael A., et al.
Publicado: (2020)

Molecular Detection of Azole-Resistant Aspergillus fumigatus in Clinical Samples
por: Buil, Jochem B., et al.
Publicado: (2018)

Antifungal Susceptibility and Mutations in the Squalene Epoxidase Gene in Dermatophytes of the Trichophyton mentagrophytes Species Complex
por: Kong, Xue, et al.
Publicado: (2021)

Laboratory Detection of Artemisinin-Resistant Plasmodium falciparum
por: Chotivanich, Kesinee, et al.
Publicado: (2014)

Transient and Sustained Bacterial Adaptation following Repeated Sublethal Exposure to Microbicides and a Novel Human Antimicrobial Peptide
por: Forbes, Sarah, et al.
Publicado: (2014)

Comparative In Vitro Activities of SMT19969, a New Antimicrobial Agent, against Clostridium difficile and 350 Gram-Positive and Gram-Negative Aerobic and Anaerobic Intestinal Flora Isolates
por: Goldstein, Ellie J. C., et al.
Publicado: (2013)

Field-Based Flow Cytometry for Ex Vivo Characterization of Plasmodium vivax and P. falciparum Antimalarial Sensitivity
por: Russell, B., et al.
Publicado: (2013)

Comparative In Vitro Activities of SMT19969, a New Antimicrobial Agent, against 162 Strains from 35 Less Frequently Recovered Intestinal Clostridium Species: Implications for Clostridium difficile Recurrence
por: Goldstein, Ellie J. C., et al.
Publicado: (2014)

Clinically and Microbiologically Derived Azithromycin Susceptibility Breakpoints for Salmonella enterica Serovars Typhi and Paratyphi A
por: Parry, Christopher M., et al.
Publicado: (2015)

In Vitro Activity of Isavuconazole and Comparators against Clinical Isolates of the Mucorales Order
por: Arendrup, Maiken Cavling, et al.
Publicado: (2015)

Phenotypically Adapted Mycobacterium tuberculosis Populations from Sputum Are Tolerant to First-Line Drugs
por: Turapov, Obolbek, et al.
Publicado: (2016)

Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance
por: Bottery, Michael J., et al.
Publicado: (2016)

Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis
por: Gold, Ben, et al.
Publicado: (2015)

pH Manipulation as a Novel Strategy for Treating Mucormycosis
por: Trzaska, Wioleta J., et al.
Publicado: (2015)

Susceptibility of Clostridium difficile Isolates of Varying Antimicrobial Resistance Phenotypes to SMT19969 and 11 Comparators
por: Freeman, Jane, et al.
Publicado: (2015)

Type III Secretion-Dependent Sensitivity of Escherichia coli O157 to Specific Ketolides
por: Fernandez-Brando, Romina J., et al.
Publicado: (2015)

In Vitro Activity of Solithromycin against Bordetella pertussis, an Emerging Respiratory Pathogen
por: Hardy, Dwight J., et al.
Publicado: (2016)

Effect of High N-Acetylcysteine Concentrations on Antibiotic Activity against a Large Collection of Respiratory Pathogens
por: Landini, Giulia, et al.
Publicado: (2016)

Development of a Novel Collagen Wound Model To Simulate the Activity and Distribution of Antimicrobials in Soft Tissue during Diabetic Foot Infection
por: Price, Bianca L., et al.
Publicado: (2016)

In Vitro Activity of Meropenem-Vaborbactam against Clinical Isolates of KPC-Positive Enterobacteriaceae
por: Hackel, Meredith A., et al.
Publicado: (2017)

Vancomycin and Clarithromycin Show Synergy against Mycobacterium abscessus In Vitro
por: Mukherjee, Devika, et al.
Publicado: (2017)

Mycobacterium abscessus Smooth and Rough Morphotypes Form Antimicrobial-Tolerant Biofilm Phenotypes but Are Killed by Acetic Acid
por: Clary, Gillian, et al.
Publicado: (2018)

Determination of MIC Distribution and Mechanisms of Decreased Susceptibility to Bedaquiline among Clinical Isolates of Mycobacterium abscessus
por: Li, Bing, et al.
Publicado: (2018)

Interaction of Bacterial Phenazines with Colistimethate in Bronchial Epithelial Cells
por: Mossine, Valeri V., et al.
Publicado: (2018)

Activity of Telavancin against Staphylococcus aureus Isolates, Including Those with Decreased Susceptibility to Ceftaroline, from Cystic Fibrosis Patients
por: Roch, Melanie, et al.
Publicado: (2018)

Heavy Metal Susceptibility of Escherichia coli Isolated from Urine Samples from Sweden, Germany, and Spain
por: Sütterlin, Susanne, et al.
Publicado: (2018)

Evaluation of the Antifungal Activity of the Novel Oral Glucan Synthase Inhibitor SCY-078, Singly and in Combination, for the Treatment of Invasive Aspergillosis
por: Ghannoum, M., et al.
Publicado: (2018)

In Vitro Activity of the Siderophore Cephalosporin, Cefiderocol, against Carbapenem-Nonsusceptible and Multidrug-Resistant Isolates of Gram-Negative Bacilli Collected Worldwide in 2014 to 2016
por: Hackel, Meredith A., et al.
Publicado: (2018)

A Diagnostic Algorithm To Investigate Pyrazinamide and Ethambutol Resistance in Rifampin-Resistant Mycobacterium tuberculosis Isolates in a Low-Incidence Setting
por: Andres, Söenke, et al.
Publicado: (2019)

Validating a 14-Drug Microtiter Plate Containing Bedaquiline and Delamanid for Large-Scale Research Susceptibility Testing of Mycobacterium tuberculosis
por: Rancoita, Paola M. V., et al.
Publicado: (2018)

Outcomes by MIC Values for Patients Treated with Isavuconazole or Voriconazole for Invasive Aspergillosis in the Phase 3 SECURE and VITAL Trials
por: Andes, David R., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3s374ogfvkehpnp6ahvo2eh8kk