Cargando…
Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma
BACKGROUND: Several animal studies have shown the roles of cytokines in regulating liver regeneration following liver resection (LR), which is a type of surgery designed to remove cancerous tumors from the liver. This study investigated how the expressions and serum levels of some pro- and anti-infl...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093046/ https://www.ncbi.nlm.nih.gov/pubmed/33987145 http://dx.doi.org/10.1155/2021/5593655 |
_version_ | 1783687732112916480 |
---|---|
author | Fathi, Farshid Sanei, Behnam Ganjalikhani Hakemi, Mazdak Saidi, Reza F. Rezaei, Abbas |
author_facet | Fathi, Farshid Sanei, Behnam Ganjalikhani Hakemi, Mazdak Saidi, Reza F. Rezaei, Abbas |
author_sort | Fathi, Farshid |
collection | PubMed |
description | BACKGROUND: Several animal studies have shown the roles of cytokines in regulating liver regeneration following liver resection (LR), which is a type of surgery designed to remove cancerous tumors from the liver. This study investigated how the expressions and serum levels of some pro- and anti-inflammatory cytokines in patients with hepatocellular carcinoma (HCC) were changed during LR. METHODS: Liver tissues from 15 patients with HCC were collected and the levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), IL-1α, IL-1 β, IL-10, and transforming growth factor-beta1 (TGF-β1) were assessed using real-time PCR assay at different times before and after LR. The serum values of TNF-α and IL-6 were also measured by ELISA. RESULTS: After 60 and 90 minutes of LR, IL-6 gene expression was significantly increased (P < 0.001 − 0.05). The same trend was also observed in TNF-α expression after 90 minutes of LR (P < 0.01). No significant changes were observed in the expressions of IL-1α, IL-1β, IL-10, and TGF-β1 before and after LR. In addition, LR had significant effects on TNF-α and IL-6 serum levels (P < 0.05 − 0.0001). CONCLUSION: Our data provided further evidence to reveal that IL-6 and TNF-α cytokines are critical to improve liver regeneration. |
format | Online Article Text |
id | pubmed-8093046 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-80930462021-05-12 Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma Fathi, Farshid Sanei, Behnam Ganjalikhani Hakemi, Mazdak Saidi, Reza F. Rezaei, Abbas Can J Gastroenterol Hepatol Research Article BACKGROUND: Several animal studies have shown the roles of cytokines in regulating liver regeneration following liver resection (LR), which is a type of surgery designed to remove cancerous tumors from the liver. This study investigated how the expressions and serum levels of some pro- and anti-inflammatory cytokines in patients with hepatocellular carcinoma (HCC) were changed during LR. METHODS: Liver tissues from 15 patients with HCC were collected and the levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), IL-1α, IL-1 β, IL-10, and transforming growth factor-beta1 (TGF-β1) were assessed using real-time PCR assay at different times before and after LR. The serum values of TNF-α and IL-6 were also measured by ELISA. RESULTS: After 60 and 90 minutes of LR, IL-6 gene expression was significantly increased (P < 0.001 − 0.05). The same trend was also observed in TNF-α expression after 90 minutes of LR (P < 0.01). No significant changes were observed in the expressions of IL-1α, IL-1β, IL-10, and TGF-β1 before and after LR. In addition, LR had significant effects on TNF-α and IL-6 serum levels (P < 0.05 − 0.0001). CONCLUSION: Our data provided further evidence to reveal that IL-6 and TNF-α cytokines are critical to improve liver regeneration. Hindawi 2021-04-23 /pmc/articles/PMC8093046/ /pubmed/33987145 http://dx.doi.org/10.1155/2021/5593655 Text en Copyright © 2021 Farshid Fathi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Fathi, Farshid Sanei, Behnam Ganjalikhani Hakemi, Mazdak Saidi, Reza F. Rezaei, Abbas Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma |
title | Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma |
title_full | Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma |
title_fullStr | Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma |
title_full_unstemmed | Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma |
title_short | Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma |
title_sort | liver resection promotes (regulates) proinflammatory cytokines in patients with hepatocellular carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093046/ https://www.ncbi.nlm.nih.gov/pubmed/33987145 http://dx.doi.org/10.1155/2021/5593655 |
work_keys_str_mv | AT fathifarshid liverresectionpromotesregulatesproinflammatorycytokinesinpatientswithhepatocellularcarcinoma AT saneibehnam liverresectionpromotesregulatesproinflammatorycytokinesinpatientswithhepatocellularcarcinoma AT ganjalikhanihakemimazdak liverresectionpromotesregulatesproinflammatorycytokinesinpatientswithhepatocellularcarcinoma AT saidirezaf liverresectionpromotesregulatesproinflammatorycytokinesinpatientswithhepatocellularcarcinoma AT rezaeiabbas liverresectionpromotesregulatesproinflammatorycytokinesinpatientswithhepatocellularcarcinoma |