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Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma

BACKGROUND: Several animal studies have shown the roles of cytokines in regulating liver regeneration following liver resection (LR), which is a type of surgery designed to remove cancerous tumors from the liver. This study investigated how the expressions and serum levels of some pro- and anti-infl...

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Autores principales: Fathi, Farshid, Sanei, Behnam, Ganjalikhani Hakemi, Mazdak, Saidi, Reza F., Rezaei, Abbas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093046/
https://www.ncbi.nlm.nih.gov/pubmed/33987145
http://dx.doi.org/10.1155/2021/5593655
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author Fathi, Farshid
Sanei, Behnam
Ganjalikhani Hakemi, Mazdak
Saidi, Reza F.
Rezaei, Abbas
author_facet Fathi, Farshid
Sanei, Behnam
Ganjalikhani Hakemi, Mazdak
Saidi, Reza F.
Rezaei, Abbas
author_sort Fathi, Farshid
collection PubMed
description BACKGROUND: Several animal studies have shown the roles of cytokines in regulating liver regeneration following liver resection (LR), which is a type of surgery designed to remove cancerous tumors from the liver. This study investigated how the expressions and serum levels of some pro- and anti-inflammatory cytokines in patients with hepatocellular carcinoma (HCC) were changed during LR. METHODS: Liver tissues from 15 patients with HCC were collected and the levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), IL-1α, IL-1 β, IL-10, and transforming growth factor-beta1 (TGF-β1) were assessed using real-time PCR assay at different times before and after LR. The serum values of TNF-α and IL-6 were also measured by ELISA. RESULTS: After 60 and 90 minutes of LR, IL-6 gene expression was significantly increased (P < 0.001 − 0.05). The same trend was also observed in TNF-α expression after 90 minutes of LR (P < 0.01). No significant changes were observed in the expressions of IL-1α, IL-1β, IL-10, and TGF-β1 before and after LR. In addition, LR had significant effects on TNF-α and IL-6 serum levels (P < 0.05 − 0.0001). CONCLUSION: Our data provided further evidence to reveal that IL-6 and TNF-α cytokines are critical to improve liver regeneration.
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spelling pubmed-80930462021-05-12 Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma Fathi, Farshid Sanei, Behnam Ganjalikhani Hakemi, Mazdak Saidi, Reza F. Rezaei, Abbas Can J Gastroenterol Hepatol Research Article BACKGROUND: Several animal studies have shown the roles of cytokines in regulating liver regeneration following liver resection (LR), which is a type of surgery designed to remove cancerous tumors from the liver. This study investigated how the expressions and serum levels of some pro- and anti-inflammatory cytokines in patients with hepatocellular carcinoma (HCC) were changed during LR. METHODS: Liver tissues from 15 patients with HCC were collected and the levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), IL-1α, IL-1 β, IL-10, and transforming growth factor-beta1 (TGF-β1) were assessed using real-time PCR assay at different times before and after LR. The serum values of TNF-α and IL-6 were also measured by ELISA. RESULTS: After 60 and 90 minutes of LR, IL-6 gene expression was significantly increased (P < 0.001 − 0.05). The same trend was also observed in TNF-α expression after 90 minutes of LR (P < 0.01). No significant changes were observed in the expressions of IL-1α, IL-1β, IL-10, and TGF-β1 before and after LR. In addition, LR had significant effects on TNF-α and IL-6 serum levels (P < 0.05 − 0.0001). CONCLUSION: Our data provided further evidence to reveal that IL-6 and TNF-α cytokines are critical to improve liver regeneration. Hindawi 2021-04-23 /pmc/articles/PMC8093046/ /pubmed/33987145 http://dx.doi.org/10.1155/2021/5593655 Text en Copyright © 2021 Farshid Fathi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Fathi, Farshid
Sanei, Behnam
Ganjalikhani Hakemi, Mazdak
Saidi, Reza F.
Rezaei, Abbas
Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma
title Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma
title_full Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma
title_fullStr Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma
title_full_unstemmed Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma
title_short Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma
title_sort liver resection promotes (regulates) proinflammatory cytokines in patients with hepatocellular carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093046/
https://www.ncbi.nlm.nih.gov/pubmed/33987145
http://dx.doi.org/10.1155/2021/5593655
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