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Insights of Outcome after Resection of Small Nonfunctioning Neuroendocrine Pancreatic Tumors
BACKGROUND: The incidence of small nonfunctioning neuroendocrine pancreatic tumors (NF-PNETs) has been increasing systematically in the last few decades. Surgical resection was once considered the treatment of choice but has been questioned in the direction of a more conservative approach for select...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093048/ https://www.ncbi.nlm.nih.gov/pubmed/33986797 http://dx.doi.org/10.1155/2021/6650386 |
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author | Figueira, Estela Regina Ramos Ribeiro, Julia Fray Ribeiro, Thiago Costa Jureidini, Ricardo Namur, Guilherme Naccache Costa, Thiago Nogueira Bacchella, Telesforo Cecconello, Ivan |
author_facet | Figueira, Estela Regina Ramos Ribeiro, Julia Fray Ribeiro, Thiago Costa Jureidini, Ricardo Namur, Guilherme Naccache Costa, Thiago Nogueira Bacchella, Telesforo Cecconello, Ivan |
author_sort | Figueira, Estela Regina Ramos |
collection | PubMed |
description | BACKGROUND: The incidence of small nonfunctioning neuroendocrine pancreatic tumors (NF-PNETs) has been increasing systematically in the last few decades. Surgical resection was once considered the treatment of choice but has been questioned in the direction of a more conservative approach for selected patients. Our aim was to analyze the outcome of surgical resection of small (≤3cm) NF-PNETs. METHODS: We retrospectively evaluated 14 patients with sporadic NF-PNETs who underwent pancreatic resection. Data were collected from patients' medical records. RESULTS: Of the 14 patients included, 35.71% were men, and the average age was 52.36 ± 20.36 years. Comorbidities were present in 92.86% of the cases. The incidence of postoperative complications was 42.86%, the 30-day mortality was zero, and the length of follow-up was 3.31 ± 3.0 years. The results of pathological evaluations revealed WHO grade I in 42.86% of cases, II in 21.43%, and neuroendocrine carcinoma in 35.71%. The median tumor size was 1.85cm (range, 0.5–3cm), and 2 cases had synchronous metastasis. The median TNM stage was IIa (range, I–IV). The disease-free and patient survival rates were 87.5% and 100% at 3 years and 43.75% and 75% at 10 years, respectively. The tumor pathological grade was significantly higher in head tumors than body-tail tumors, but there were no differences with respect to tumor size and TNM staging. CONCLUSION: A surgical approach to treat small sporadic NF-PNETs is safe with low mortality and high patient survival. Based on these data, small pancreatic head tumors can be more aggressive, suggesting that surgical resection is still the best option to treat small nonfunctioning PNETS. Thus, conservative treatment should be indicated very cautiously for only cases with absolute contraindications for surgery. |
format | Online Article Text |
id | pubmed-8093048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-80930482021-05-12 Insights of Outcome after Resection of Small Nonfunctioning Neuroendocrine Pancreatic Tumors Figueira, Estela Regina Ramos Ribeiro, Julia Fray Ribeiro, Thiago Costa Jureidini, Ricardo Namur, Guilherme Naccache Costa, Thiago Nogueira Bacchella, Telesforo Cecconello, Ivan Gastroenterol Res Pract Research Article BACKGROUND: The incidence of small nonfunctioning neuroendocrine pancreatic tumors (NF-PNETs) has been increasing systematically in the last few decades. Surgical resection was once considered the treatment of choice but has been questioned in the direction of a more conservative approach for selected patients. Our aim was to analyze the outcome of surgical resection of small (≤3cm) NF-PNETs. METHODS: We retrospectively evaluated 14 patients with sporadic NF-PNETs who underwent pancreatic resection. Data were collected from patients' medical records. RESULTS: Of the 14 patients included, 35.71% were men, and the average age was 52.36 ± 20.36 years. Comorbidities were present in 92.86% of the cases. The incidence of postoperative complications was 42.86%, the 30-day mortality was zero, and the length of follow-up was 3.31 ± 3.0 years. The results of pathological evaluations revealed WHO grade I in 42.86% of cases, II in 21.43%, and neuroendocrine carcinoma in 35.71%. The median tumor size was 1.85cm (range, 0.5–3cm), and 2 cases had synchronous metastasis. The median TNM stage was IIa (range, I–IV). The disease-free and patient survival rates were 87.5% and 100% at 3 years and 43.75% and 75% at 10 years, respectively. The tumor pathological grade was significantly higher in head tumors than body-tail tumors, but there were no differences with respect to tumor size and TNM staging. CONCLUSION: A surgical approach to treat small sporadic NF-PNETs is safe with low mortality and high patient survival. Based on these data, small pancreatic head tumors can be more aggressive, suggesting that surgical resection is still the best option to treat small nonfunctioning PNETS. Thus, conservative treatment should be indicated very cautiously for only cases with absolute contraindications for surgery. Hindawi 2021-04-24 /pmc/articles/PMC8093048/ /pubmed/33986797 http://dx.doi.org/10.1155/2021/6650386 Text en Copyright © 2021 Estela Regina Ramos Figueira et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Figueira, Estela Regina Ramos Ribeiro, Julia Fray Ribeiro, Thiago Costa Jureidini, Ricardo Namur, Guilherme Naccache Costa, Thiago Nogueira Bacchella, Telesforo Cecconello, Ivan Insights of Outcome after Resection of Small Nonfunctioning Neuroendocrine Pancreatic Tumors |
title | Insights of Outcome after Resection of Small Nonfunctioning Neuroendocrine Pancreatic Tumors |
title_full | Insights of Outcome after Resection of Small Nonfunctioning Neuroendocrine Pancreatic Tumors |
title_fullStr | Insights of Outcome after Resection of Small Nonfunctioning Neuroendocrine Pancreatic Tumors |
title_full_unstemmed | Insights of Outcome after Resection of Small Nonfunctioning Neuroendocrine Pancreatic Tumors |
title_short | Insights of Outcome after Resection of Small Nonfunctioning Neuroendocrine Pancreatic Tumors |
title_sort | insights of outcome after resection of small nonfunctioning neuroendocrine pancreatic tumors |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093048/ https://www.ncbi.nlm.nih.gov/pubmed/33986797 http://dx.doi.org/10.1155/2021/6650386 |
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