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Inactivation of TOPK Caused by Hyperglycemia Blocks Diabetic Heart Sensitivity to Sevoflurane Postconditioning by Impairing the PTEN/PI3K/Akt Signaling

The cardioprotective effect of sevoflurane postconditioning (SPostC) is lost in diabetes that is associated with cardiac phosphatase and tensin homologue on chromosome 10 (PTEN) activation and phosphoinositide 3-kinase (PI3K)/Akt inactivation. T-LAK cell-originated protein kinase (TOPK), a mitogen-a...

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Detalles Bibliográficos
Autores principales:	Gao, Sumin, Wang, Rong, Dong, Siwei, Wu, Jing, Perek, Bartłomiej, Xia, Zhengyuan, Yao, Shanglong, Wang, Tingting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093075/ https://www.ncbi.nlm.nih.gov/pubmed/33986917 http://dx.doi.org/10.1155/2021/6657529

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