Functional Adrenocortical Carcinoma: A Rare Case With Thrombus Extension Into the Inferior Vena Cava and a Presentation of Cushing Syndrome

Adrenocortical carcinoma (ACC) is a rare, highly malignant endocrine tumor, often associated with a poor prognosis. Most patients who develop ACC are either children of ages 1-6, or adults in their fourth to fifth decade of life. Individuals with a functional cortisol-secreting ACC frequently presen...

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Autores principales: Southall, Thomas M, MacDonald, Morgan, Acker, Matthew R, Organ, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Urology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093109/
https://www.ncbi.nlm.nih.gov/pubmed/33959434
http://dx.doi.org/10.7759/cureus.14239
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author Southall, Thomas M
MacDonald, Morgan
Acker, Matthew R
Organ, Michael
author_facet Southall, Thomas M
MacDonald, Morgan
Acker, Matthew R
Organ, Michael
author_sort Southall, Thomas M
collection PubMed
description Adrenocortical carcinoma (ACC) is a rare, highly malignant endocrine tumor, often associated with a poor prognosis. Most patients who develop ACC are either children of ages 1-6, or adults in their fourth to fifth decade of life. Individuals with a functional cortisol-secreting ACC frequently present with Cushing syndrome. We report a case of an 18-year-old male who was found to have a large ACC tumor, with thrombus extension into the inferior vena cava (IVC), after presenting with Cushing syndrome. ACC presents a challenging scenario for physicians as surgical resection remains the only form of curative therapy, however, despite such treatment many patients quickly develop metastases.
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spelling pubmed-80931092021-05-05 Functional Adrenocortical Carcinoma: A Rare Case With Thrombus Extension Into the Inferior Vena Cava and a Presentation of Cushing Syndrome Southall, Thomas M MacDonald, Morgan Acker, Matthew R Organ, Michael Cureus Urology Adrenocortical carcinoma (ACC) is a rare, highly malignant endocrine tumor, often associated with a poor prognosis. Most patients who develop ACC are either children of ages 1-6, or adults in their fourth to fifth decade of life. Individuals with a functional cortisol-secreting ACC frequently present with Cushing syndrome. We report a case of an 18-year-old male who was found to have a large ACC tumor, with thrombus extension into the inferior vena cava (IVC), after presenting with Cushing syndrome. ACC presents a challenging scenario for physicians as surgical resection remains the only form of curative therapy, however, despite such treatment many patients quickly develop metastases. Cureus 2021-04-01 /pmc/articles/PMC8093109/ /pubmed/33959434 http://dx.doi.org/10.7759/cureus.14239 Text en Copyright © 2021, Southall et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Urology
Southall, Thomas M
MacDonald, Morgan
Acker, Matthew R
Organ, Michael
Functional Adrenocortical Carcinoma: A Rare Case With Thrombus Extension Into the Inferior Vena Cava and a Presentation of Cushing Syndrome
title Functional Adrenocortical Carcinoma: A Rare Case With Thrombus Extension Into the Inferior Vena Cava and a Presentation of Cushing Syndrome
title_full Functional Adrenocortical Carcinoma: A Rare Case With Thrombus Extension Into the Inferior Vena Cava and a Presentation of Cushing Syndrome
title_fullStr Functional Adrenocortical Carcinoma: A Rare Case With Thrombus Extension Into the Inferior Vena Cava and a Presentation of Cushing Syndrome
title_full_unstemmed Functional Adrenocortical Carcinoma: A Rare Case With Thrombus Extension Into the Inferior Vena Cava and a Presentation of Cushing Syndrome
title_short Functional Adrenocortical Carcinoma: A Rare Case With Thrombus Extension Into the Inferior Vena Cava and a Presentation of Cushing Syndrome
title_sort functional adrenocortical carcinoma: a rare case with thrombus extension into the inferior vena cava and a presentation of cushing syndrome
topic Urology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093109/
https://www.ncbi.nlm.nih.gov/pubmed/33959434
http://dx.doi.org/10.7759/cureus.14239
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