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Genetically Informed Regression Analysis: Application to Aggression Prediction by Inattention and Hyperactivity in Children and Adults

We present a procedure to simultaneously fit a genetic covariance structure model and a regression model to multivariate data from mono- and dizygotic twin pairs to test for the prediction of a dependent trait by multiple correlated predictors. We applied the model to aggressive behavior as an outco...

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Autores principales: Boomsma, Dorret I., van Beijsterveldt, Toos C. E. M., Odintsova, Veronika V., Neale, Michael C., Dolan, Conor V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093158/
https://www.ncbi.nlm.nih.gov/pubmed/33259025
http://dx.doi.org/10.1007/s10519-020-10025-9
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author Boomsma, Dorret I.
van Beijsterveldt, Toos C. E. M.
Odintsova, Veronika V.
Neale, Michael C.
Dolan, Conor V.
author_facet Boomsma, Dorret I.
van Beijsterveldt, Toos C. E. M.
Odintsova, Veronika V.
Neale, Michael C.
Dolan, Conor V.
author_sort Boomsma, Dorret I.
collection PubMed
description We present a procedure to simultaneously fit a genetic covariance structure model and a regression model to multivariate data from mono- and dizygotic twin pairs to test for the prediction of a dependent trait by multiple correlated predictors. We applied the model to aggressive behavior as an outcome trait and investigated the prediction of aggression from inattention (InA) and hyperactivity (HA) in two age groups. Predictions were examined in twins with an average age of 10 years (11,345 pairs), and in adult twins with an average age of 30 years (7433 pairs). All phenotypes were assessed by the same, but age-appropriate, instruments in children and adults. Because of the different genetic architecture of aggression, InA and HA, a model was fitted to these data that specified additive and non-additive genetic factors (A and D) plus common and unique environmental (C and E) influences. Given appropriate identifying constraints, this ADCE model is identified in trivariate data. We obtained different results for the prediction of aggression in children, where HA was the more important predictor, and in adults, where InA was the more important predictor. In children, about 36% of the total aggression variance was explained by the genetic and environmental components of HA and InA. Most of this was explained by the genetic components of HA and InA, i.e., 29.7%, with 22.6% due to the genetic component of HA. In adults, about 21% of the aggression variance was explained. Most was this was again explained by the genetic components of InA and HA (16.2%), with 8.6% due to the genetic component of InA. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10519-020-10025-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-80931582021-05-05 Genetically Informed Regression Analysis: Application to Aggression Prediction by Inattention and Hyperactivity in Children and Adults Boomsma, Dorret I. van Beijsterveldt, Toos C. E. M. Odintsova, Veronika V. Neale, Michael C. Dolan, Conor V. Behav Genet Original Research We present a procedure to simultaneously fit a genetic covariance structure model and a regression model to multivariate data from mono- and dizygotic twin pairs to test for the prediction of a dependent trait by multiple correlated predictors. We applied the model to aggressive behavior as an outcome trait and investigated the prediction of aggression from inattention (InA) and hyperactivity (HA) in two age groups. Predictions were examined in twins with an average age of 10 years (11,345 pairs), and in adult twins with an average age of 30 years (7433 pairs). All phenotypes were assessed by the same, but age-appropriate, instruments in children and adults. Because of the different genetic architecture of aggression, InA and HA, a model was fitted to these data that specified additive and non-additive genetic factors (A and D) plus common and unique environmental (C and E) influences. Given appropriate identifying constraints, this ADCE model is identified in trivariate data. We obtained different results for the prediction of aggression in children, where HA was the more important predictor, and in adults, where InA was the more important predictor. In children, about 36% of the total aggression variance was explained by the genetic and environmental components of HA and InA. Most of this was explained by the genetic components of HA and InA, i.e., 29.7%, with 22.6% due to the genetic component of HA. In adults, about 21% of the aggression variance was explained. Most was this was again explained by the genetic components of InA and HA (16.2%), with 8.6% due to the genetic component of InA. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10519-020-10025-9) contains supplementary material, which is available to authorized users. Springer US 2020-12-01 2021 /pmc/articles/PMC8093158/ /pubmed/33259025 http://dx.doi.org/10.1007/s10519-020-10025-9 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Research
Boomsma, Dorret I.
van Beijsterveldt, Toos C. E. M.
Odintsova, Veronika V.
Neale, Michael C.
Dolan, Conor V.
Genetically Informed Regression Analysis: Application to Aggression Prediction by Inattention and Hyperactivity in Children and Adults
title Genetically Informed Regression Analysis: Application to Aggression Prediction by Inattention and Hyperactivity in Children and Adults
title_full Genetically Informed Regression Analysis: Application to Aggression Prediction by Inattention and Hyperactivity in Children and Adults
title_fullStr Genetically Informed Regression Analysis: Application to Aggression Prediction by Inattention and Hyperactivity in Children and Adults
title_full_unstemmed Genetically Informed Regression Analysis: Application to Aggression Prediction by Inattention and Hyperactivity in Children and Adults
title_short Genetically Informed Regression Analysis: Application to Aggression Prediction by Inattention and Hyperactivity in Children and Adults
title_sort genetically informed regression analysis: application to aggression prediction by inattention and hyperactivity in children and adults
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093158/
https://www.ncbi.nlm.nih.gov/pubmed/33259025
http://dx.doi.org/10.1007/s10519-020-10025-9
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