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Prevalence and predictive factors of osteoporosis in Thai systemic sclerosis
Systemic sclerosis (SSc) is recognized as a chronic inflammatory disease and several SSc-associated factors may increase the risk of osteoporosis and its related fractures. To determine the prevalence and predictive factors of osteoporosis in Thai SSc, a cross-sectional study was designed in adult S...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093198/ https://www.ncbi.nlm.nih.gov/pubmed/33941800 http://dx.doi.org/10.1038/s41598-021-88792-6 |
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author | Chuealee, Wiriya Foocharoen, Chingching Mahakkanukrauh, Ajanee Suwannaroj, Siraphop Pongchaiyakul, Chatlert Nanagara, Ratanavadee |
author_facet | Chuealee, Wiriya Foocharoen, Chingching Mahakkanukrauh, Ajanee Suwannaroj, Siraphop Pongchaiyakul, Chatlert Nanagara, Ratanavadee |
author_sort | Chuealee, Wiriya |
collection | PubMed |
description | Systemic sclerosis (SSc) is recognized as a chronic inflammatory disease and several SSc-associated factors may increase the risk of osteoporosis and its related fractures. To determine the prevalence and predictive factors of osteoporosis in Thai SSc, a cross-sectional study was designed in adult SSc patients at Scleroderma clinic, Khon Kaen University Hospital. The prevalence of osteoporosis with the 95% confidence interval (CI) were determined and the odds ratio (OR) with 95%CI were assessed the clinical association with osteoporosis. A total of 205 SSc patients were recruited with the female to male ratio of 2.7:1. The majority of cases were diffuse SSc subset (83.4%) with a disease duration < 5 years (62.9%). The overall prevalence of osteoporosis was 29.3% (95%CI 23.1–36.0). After an age adjusted analysis, the respective prevalence of osteoporosis at lumbar spine (LS) in women and men was 26.3% and 10%, while the prevalence of osteoporosis at the femoral neck (FN) in women and men was 11% and 2.1%. Low BMI (≤ 18.5 kg/m(2)) and menopause were associated with osteoporosis at both the LS and FN. Using multivariate analysis, low BMI and menopause were associated with osteoporosis at LS (OR 7.78 and 5.32, respectively), while low BMI was also associated with osteoporosis at LS in pre-menopausal women. In conclusion, the prevalence of osteoporosis in Thai SSc was 29.3%. Osteoporosis at the LS is more common than FN in both men and women. Low BMI was associated with osteoporosis in overall SSc and pre-menopausal women, while only menopause was associated with osteoporosis at the FN. |
format | Online Article Text |
id | pubmed-8093198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80931982021-05-05 Prevalence and predictive factors of osteoporosis in Thai systemic sclerosis Chuealee, Wiriya Foocharoen, Chingching Mahakkanukrauh, Ajanee Suwannaroj, Siraphop Pongchaiyakul, Chatlert Nanagara, Ratanavadee Sci Rep Article Systemic sclerosis (SSc) is recognized as a chronic inflammatory disease and several SSc-associated factors may increase the risk of osteoporosis and its related fractures. To determine the prevalence and predictive factors of osteoporosis in Thai SSc, a cross-sectional study was designed in adult SSc patients at Scleroderma clinic, Khon Kaen University Hospital. The prevalence of osteoporosis with the 95% confidence interval (CI) were determined and the odds ratio (OR) with 95%CI were assessed the clinical association with osteoporosis. A total of 205 SSc patients were recruited with the female to male ratio of 2.7:1. The majority of cases were diffuse SSc subset (83.4%) with a disease duration < 5 years (62.9%). The overall prevalence of osteoporosis was 29.3% (95%CI 23.1–36.0). After an age adjusted analysis, the respective prevalence of osteoporosis at lumbar spine (LS) in women and men was 26.3% and 10%, while the prevalence of osteoporosis at the femoral neck (FN) in women and men was 11% and 2.1%. Low BMI (≤ 18.5 kg/m(2)) and menopause were associated with osteoporosis at both the LS and FN. Using multivariate analysis, low BMI and menopause were associated with osteoporosis at LS (OR 7.78 and 5.32, respectively), while low BMI was also associated with osteoporosis at LS in pre-menopausal women. In conclusion, the prevalence of osteoporosis in Thai SSc was 29.3%. Osteoporosis at the LS is more common than FN in both men and women. Low BMI was associated with osteoporosis in overall SSc and pre-menopausal women, while only menopause was associated with osteoporosis at the FN. Nature Publishing Group UK 2021-05-03 /pmc/articles/PMC8093198/ /pubmed/33941800 http://dx.doi.org/10.1038/s41598-021-88792-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Chuealee, Wiriya Foocharoen, Chingching Mahakkanukrauh, Ajanee Suwannaroj, Siraphop Pongchaiyakul, Chatlert Nanagara, Ratanavadee Prevalence and predictive factors of osteoporosis in Thai systemic sclerosis |
title | Prevalence and predictive factors of osteoporosis in Thai systemic sclerosis |
title_full | Prevalence and predictive factors of osteoporosis in Thai systemic sclerosis |
title_fullStr | Prevalence and predictive factors of osteoporosis in Thai systemic sclerosis |
title_full_unstemmed | Prevalence and predictive factors of osteoporosis in Thai systemic sclerosis |
title_short | Prevalence and predictive factors of osteoporosis in Thai systemic sclerosis |
title_sort | prevalence and predictive factors of osteoporosis in thai systemic sclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093198/ https://www.ncbi.nlm.nih.gov/pubmed/33941800 http://dx.doi.org/10.1038/s41598-021-88792-6 |
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