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Neurovascular coupling (NVC) in newborns using processed EEG versus amplitude-EEG

There is a critical need for development of real time physiological biomarkers for birth asphyxia that constitutes a major global public health burden. Our recent study (Scientific Reports, V10:9183, 2020) established a novel non-invasive neurovascular coupling (NVC) assessment in newborns using dyn...

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Autores principales: Das, Yudhajit, Wang, Xinlong, Kota, Srinivas, Zhang, Rong, Liu, Hanli, Chalak, Lina F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093202/
https://www.ncbi.nlm.nih.gov/pubmed/33941837
http://dx.doi.org/10.1038/s41598-021-88849-6
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author Das, Yudhajit
Wang, Xinlong
Kota, Srinivas
Zhang, Rong
Liu, Hanli
Chalak, Lina F.
author_facet Das, Yudhajit
Wang, Xinlong
Kota, Srinivas
Zhang, Rong
Liu, Hanli
Chalak, Lina F.
author_sort Das, Yudhajit
collection PubMed
description There is a critical need for development of real time physiological biomarkers for birth asphyxia that constitutes a major global public health burden. Our recent study (Scientific Reports, V10:9183, 2020) established a novel non-invasive neurovascular coupling (NVC) assessment in newborns using dynamic wavelet transform coherence (WTC) analysis irrespective of different aEEG algorithms. As an extended study, the current paper examines whether the variability in processed EEG and amplitude-EEG (aEEG) outputs would impact the determination of NVC in newborns with encephalopathy. Concurrent processed EEG tracings and regional near infrared spectroscopy (NIRS)-based cerebral tissue oxygen saturation (SctO2) readings during a period of twenty hours in their first day of life were selected and processed in this study. After bandpass-filtered in 2–15 Hz, rectified, and down-sampled at 0.21 Hz, the processed EEG tracings along with NIRS-SctO2 (0.21 Hz) were used to perform WTC analysis, followed by comparison of WTC-metrics between SctO2-processed EEG coherence and SctO2-aEEG coherence using Bland–Altman statistics. Our results demonstrated high and significant correlation (R2 = 0.96, p < 0.001) between NVC assessments by SctO2-processed EEG and SctO2-aEEG coherence, confirming that band-passed, rectified, and down-sampled processed EEG, or aEEG, can be paired with NIRS-SctO2 to assess NVC in newborns with encephalopathy. Findings indicate the feasibility of a simpler approach to NVC in neonates by using directly processed EEG, instead of aEEG.
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spelling pubmed-80932022021-05-05 Neurovascular coupling (NVC) in newborns using processed EEG versus amplitude-EEG Das, Yudhajit Wang, Xinlong Kota, Srinivas Zhang, Rong Liu, Hanli Chalak, Lina F. Sci Rep Article There is a critical need for development of real time physiological biomarkers for birth asphyxia that constitutes a major global public health burden. Our recent study (Scientific Reports, V10:9183, 2020) established a novel non-invasive neurovascular coupling (NVC) assessment in newborns using dynamic wavelet transform coherence (WTC) analysis irrespective of different aEEG algorithms. As an extended study, the current paper examines whether the variability in processed EEG and amplitude-EEG (aEEG) outputs would impact the determination of NVC in newborns with encephalopathy. Concurrent processed EEG tracings and regional near infrared spectroscopy (NIRS)-based cerebral tissue oxygen saturation (SctO2) readings during a period of twenty hours in their first day of life were selected and processed in this study. After bandpass-filtered in 2–15 Hz, rectified, and down-sampled at 0.21 Hz, the processed EEG tracings along with NIRS-SctO2 (0.21 Hz) were used to perform WTC analysis, followed by comparison of WTC-metrics between SctO2-processed EEG coherence and SctO2-aEEG coherence using Bland–Altman statistics. Our results demonstrated high and significant correlation (R2 = 0.96, p < 0.001) between NVC assessments by SctO2-processed EEG and SctO2-aEEG coherence, confirming that band-passed, rectified, and down-sampled processed EEG, or aEEG, can be paired with NIRS-SctO2 to assess NVC in newborns with encephalopathy. Findings indicate the feasibility of a simpler approach to NVC in neonates by using directly processed EEG, instead of aEEG. Nature Publishing Group UK 2021-05-03 /pmc/articles/PMC8093202/ /pubmed/33941837 http://dx.doi.org/10.1038/s41598-021-88849-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Das, Yudhajit
Wang, Xinlong
Kota, Srinivas
Zhang, Rong
Liu, Hanli
Chalak, Lina F.
Neurovascular coupling (NVC) in newborns using processed EEG versus amplitude-EEG
title Neurovascular coupling (NVC) in newborns using processed EEG versus amplitude-EEG
title_full Neurovascular coupling (NVC) in newborns using processed EEG versus amplitude-EEG
title_fullStr Neurovascular coupling (NVC) in newborns using processed EEG versus amplitude-EEG
title_full_unstemmed Neurovascular coupling (NVC) in newborns using processed EEG versus amplitude-EEG
title_short Neurovascular coupling (NVC) in newborns using processed EEG versus amplitude-EEG
title_sort neurovascular coupling (nvc) in newborns using processed eeg versus amplitude-eeg
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093202/
https://www.ncbi.nlm.nih.gov/pubmed/33941837
http://dx.doi.org/10.1038/s41598-021-88849-6
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