Cargando…

Prognostic relevance of the hexosamine biosynthesis pathway activation in leiomyosarcoma

Metabolic reprogramming of tumor cells and the increase of glucose uptake is one of the hallmarks of cancer. In order to identify metabolic pathways activated in leiomyosarcoma (LMS), we analyzed transcriptomic profiles of distinct subtypes of LMS in several datasets. Primary, recurrent and metastat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tolwani, Angela, Matusiak, Magdalena, Bui, Nam, Forgó, Erna, Varma, Sushama, Baratto, Lucia, Iagaru, Andrei, Lazar, Alexander J., van de Rijn, Matt, Przybyl, Joanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093268/ https://www.ncbi.nlm.nih.gov/pubmed/33941787 http://dx.doi.org/10.1038/s41525-021-00193-w

Ejemplares similares

Molecular subtyping of leiomyosarcoma with 3′ end RNA sequencing
por: Guo, Xiangqian, et al.
Publicado: (2015)

Detection of Circulating Tumor DNA in Patients With Uterine Leiomyomas
por: Przybyl, Joanna, et al.
Publicado: (2019)

The Hexosamine Biosynthesis Pathway: Regulation and Function
por: Paneque, Alysta, et al.
Publicado: (2023)

Targeting a critical step in fungal hexosamine biosynthesis
por: Lockhart, Deborah E. A., et al.
Publicado: (2020)

The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae
por: Alme, Emma B., et al.
Publicado: (2020)

CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation
por: Al-Jazrawe, Mushriq, et al.
Publicado: (2023)

Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
por: Tran, Diem Hong, et al.
Publicado: (2020)

Current knowledge and potential intervention of hexosamine biosynthesis pathway in lung cancer
por: Zou, Yi, et al.
Publicado: (2023)

Acute Regulation of Cardiac Metabolism by the Hexosamine Biosynthesis Pathway and Protein O-GlcNAcylation
por: Laczy, Boglárka, et al.
Publicado: (2011)

Flipping the script on macrophages in leiomyosarcoma
por: Edris, Badreddin, et al.
Publicado: (2012)

A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk
por: Gentles, Andrew J., et al.
Publicado: (2020)

Hexosamine Biosynthesis Is a Possible Mechanism Underlying Hypoxia’s Effects on Lipid Metabolism in Human Adipocytes
por: O’Rourke, Robert W., et al.
Publicado: (2013)

The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1-mutant lung cancer
por: Kim, Jiyeon, et al.
Publicado: (2020)

Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma
por: Przybyl, Joanna, et al.
Publicado: (2019)

First characterization of glucose flux through the hexosamine biosynthesis pathway (HBP) in ex vivo mouse heart
por: Olson, Aaron K., et al.
Publicado: (2020)

Dietary glucosamine overcomes the defects in αβ-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis
por: Werlen, Guy, et al.
Publicado: (2022)

The hexosamine biosynthesis pathway-related gene signature correlates with immune infiltration and predicts prognosis of patients with osteosarcoma
por: Su, Zexin, et al.
Publicado: (2022)

A clinico-genomic analysis of soft tissue sarcoma patients reveals CDKN2A deletion as a biomarker for poor prognosis
por: Bui, Nam Q., et al.
Publicado: (2019)

Identification of hexosamine biosynthesis pathway as a novel prognostic signature and its correlation with immune infiltration in bladder cancer
por: Cui, Yangyan, et al.
Publicado: (2022)

Glutamine is a substrate for glycosylation and CA19-9 biosynthesis through hexosamine biosynthetic pathway in pancreatic cancer
por: Liu, Chen, et al.
Publicado: (2023)

The significance of serum hexosamine levels in patients with cancer.
por: Spiers, A. S., et al.
Publicado: (1966)

Self-Organizing Maps for Cellular In Silico Staining and Cell Substate Classification
por: Yuan, Edwin, et al.
Publicado: (2021)

Detection of MDM2 amplification by shallow whole genome sequencing of cell-free DNA of patients with dedifferentiated liposarcoma
por: Przybyl, Joanna, et al.
Publicado: (2022)

Glutamine deprivation triggers NAGK-dependent hexosamine salvage
por: Campbell, Sydney, et al.
Publicado: (2021)

Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence
por: Gitenay, D, et al.
Publicado: (2014)

Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence
por: Gitenay, D, et al.
Publicado: (2014)

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer
por: Akella, Neha M., et al.
Publicado: (2019)

The dual role of the hexosamine biosynthetic pathway in cardiac physiology and pathophysiology
por: Cairns, Megan, et al.
Publicado: (2022)

Glucose starvation induces cell death in K-ras-transformed cells by interfering with the hexosamine biosynthesis pathway and activating the unfolded protein response
por: Palorini, R, et al.
Publicado: (2013)

Glucose starvation induces cell death in K-ras-transformed cells by interfering with the hexosamine biosynthesis pathway and activating the unfolded protein response
por: Palorini, R, et al.
Publicado: (2013)

Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity
por: Chatterjee, Anupriya, et al.
Publicado: (2020)

Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer
por: Kaushik, Akash K., et al.
Publicado: (2016)

Hijacking the Hexosamine Biosynthetic Pathway to Promote EMT-Mediated Neoplastic Phenotypes
por: Taparra, Kekoa, et al.
Publicado: (2016)

Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways
por: Ryczko, Michael C., et al.
Publicado: (2016)

Hyperglycemia-induced downregulation of apolipoprotein M expression is not via the hexosamine pathway
por: Jiang, Bo, et al.
Publicado: (2015)

Differential hexosamine biosynthetic pathway gene expression with type 2 diabetes
por: Coomer, Megan, et al.
Publicado: (2014)

The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring
por: Chiaradonna, Ferdinando, et al.
Publicado: (2018)

Hexosamine Biosynthetic Pathway and Glycosylation Regulate Cell Migration in Melanoma Cells
por: de Queiroz, Rafaela Muniz, et al.
Publicado: (2019)

Hyperglycemia exacerbates colon cancer malignancy through hexosamine biosynthetic pathway
por: Vasconcelos-dos-Santos, A, et al.
Publicado: (2017)

Hexosamine pathway activation improves memory but does not extend lifespan in mice
por: Allmeroth, Kira, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mlfm9kdpji1g59268f59i97gbu