A drug-repositioning screen using splicing-sensitive fluorescent reporters identifies novel modulators of VEGF-A splicing with anti-angiogenic properties

Alternative splicing of the vascular endothelial growth factor A (VEGF-A) terminal exon generates two protein families with differing functions. Pro-angiogenic VEGF-A(xxx)a isoforms are produced via selection of the proximal 3′ splice site of the terminal exon. Use of an alternative distal splice si...

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Detalles Bibliográficos
Autores principales: Star, Eleanor, Stevens, Megan, Gooding, Clare, Smith, Christopher W. J., Li, Ling, Ayine, Monica Lamici, Harper, Steve J., Bates, David O., Oltean, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093282/
https://www.ncbi.nlm.nih.gov/pubmed/33941763
http://dx.doi.org/10.1038/s41389-021-00323-0

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