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The Role of Non-coding RNAs in Diabetic Nephropathy-Related Oxidative Stress
Diabetic nephropathy (DN) is one of the main complications of diabetes and the main cause of diabetic end-stage renal disease, which is often fatal. DN is usually characterized by progressive renal interstitial fibrosis, which is closely related to the excessive accumulation of extracellular matrix...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093385/ https://www.ncbi.nlm.nih.gov/pubmed/33959621 http://dx.doi.org/10.3389/fmed.2021.626423 |
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author | He, Xiaoyun Kuang, Gaoyan Zuo, Yi Li, Shuangxi Zhou, Suxian Ou, Chunlin |
author_facet | He, Xiaoyun Kuang, Gaoyan Zuo, Yi Li, Shuangxi Zhou, Suxian Ou, Chunlin |
author_sort | He, Xiaoyun |
collection | PubMed |
description | Diabetic nephropathy (DN) is one of the main complications of diabetes and the main cause of diabetic end-stage renal disease, which is often fatal. DN is usually characterized by progressive renal interstitial fibrosis, which is closely related to the excessive accumulation of extracellular matrix and oxidative stress. Non-coding RNAs (ncRNAs) are RNA molecules expressed in eukaryotic cells that are not translated into proteins. They are widely involved in the regulation of biological processes, such as, chromatin remodeling, transcription, post-transcriptional modification, and signal transduction. Recent studies have shown that ncRNAs play an important role in the occurrence and development of DN and participate in the regulation of oxidative stress in DN. This review clarifies the functions and mechanisms of ncRNAs in DN-related oxidative stress, providing valuable insights into the prevention, early diagnosis, and molecular therapeutic targets of DN. |
format | Online Article Text |
id | pubmed-8093385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80933852021-05-05 The Role of Non-coding RNAs in Diabetic Nephropathy-Related Oxidative Stress He, Xiaoyun Kuang, Gaoyan Zuo, Yi Li, Shuangxi Zhou, Suxian Ou, Chunlin Front Med (Lausanne) Medicine Diabetic nephropathy (DN) is one of the main complications of diabetes and the main cause of diabetic end-stage renal disease, which is often fatal. DN is usually characterized by progressive renal interstitial fibrosis, which is closely related to the excessive accumulation of extracellular matrix and oxidative stress. Non-coding RNAs (ncRNAs) are RNA molecules expressed in eukaryotic cells that are not translated into proteins. They are widely involved in the regulation of biological processes, such as, chromatin remodeling, transcription, post-transcriptional modification, and signal transduction. Recent studies have shown that ncRNAs play an important role in the occurrence and development of DN and participate in the regulation of oxidative stress in DN. This review clarifies the functions and mechanisms of ncRNAs in DN-related oxidative stress, providing valuable insights into the prevention, early diagnosis, and molecular therapeutic targets of DN. Frontiers Media S.A. 2021-04-20 /pmc/articles/PMC8093385/ /pubmed/33959621 http://dx.doi.org/10.3389/fmed.2021.626423 Text en Copyright © 2021 He, Kuang, Zuo, Li, Zhou and Ou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine He, Xiaoyun Kuang, Gaoyan Zuo, Yi Li, Shuangxi Zhou, Suxian Ou, Chunlin The Role of Non-coding RNAs in Diabetic Nephropathy-Related Oxidative Stress |
title | The Role of Non-coding RNAs in Diabetic Nephropathy-Related Oxidative Stress |
title_full | The Role of Non-coding RNAs in Diabetic Nephropathy-Related Oxidative Stress |
title_fullStr | The Role of Non-coding RNAs in Diabetic Nephropathy-Related Oxidative Stress |
title_full_unstemmed | The Role of Non-coding RNAs in Diabetic Nephropathy-Related Oxidative Stress |
title_short | The Role of Non-coding RNAs in Diabetic Nephropathy-Related Oxidative Stress |
title_sort | role of non-coding rnas in diabetic nephropathy-related oxidative stress |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093385/ https://www.ncbi.nlm.nih.gov/pubmed/33959621 http://dx.doi.org/10.3389/fmed.2021.626423 |
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