β-TrCP1 facilitates cell cycle checkpoint activation, DNA repair, and cell survival through ablation of β-TrCP2 in response to genotoxic stress

F-box proteins β-TrCP1 and β-TrCP2 are paralogs present in the human genome. They control several cellular processes including cell cycle and DNA damage signaling. Moreover, it is reported that they facilitate DNA damage-induced accumulation of p53 by directing proteasomal degradation of MDM2, a pro...

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Detalles Bibliográficos
Autores principales: Islam, Sehbanul, Dutta, Parul, Sahay, Osheen, Santra, Manas Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093472/
https://www.ncbi.nlm.nih.gov/pubmed/33676897
http://dx.doi.org/10.1016/j.jbc.2021.100511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093472/
https://www.ncbi.nlm.nih.gov/pubmed/33676897
http://dx.doi.org/10.1016/j.jbc.2021.100511

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